Cited 38 times in
EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli
DC Field | Value | Language |
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dc.contributor.author | 박전한 | - |
dc.contributor.author | 이재면 | - |
dc.date.accessioned | 2015-07-14T17:25:15Z | - |
dc.date.available | 2015-07-14T17:25:15Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112846 | - |
dc.description.abstract | In addition to functioning as a transcriptional transactivator, Epstein-Barr virus EBNA2 interacts with Nur77 to protect against Nur77-mediated apoptosis. Estrogen-regulated EBNA2 in EREB2-5 cells was replaced by either EBNA2 or EBNA2 with a deletion of conserved region 4 (EBNA2ΔCR4). Both EBNA2-converted and EBNA2ΔCR4-converted EREB2-5 cells grew in the absence of estrogen and expressed LMP1. Treatment with tumor necrosis factor alpha did not induce apoptosis of EBNA2- or EBNA2ΔCR4-expressing cells, but EBNA2ΔCR4 cells were susceptible to etoposide and 5-fluorouracil, Nur77-mediated inducers of apoptosis. Thus, EBNA2 protects B cells against specific apoptotic agents against which LMP1 is not effective. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 12694~12697 | - |
dc.relation.isPartOf | JOURNAL OF VIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Kyoung-Ho Lee | - |
dc.contributor.googleauthor | S. Diane Hayward | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Bettina Kempkes | - |
dc.contributor.googleauthor | Paul D. Ling | - |
dc.contributor.googleauthor | Christopher J. Farrell | - |
dc.identifier.doi | 10.1128/JVI.78.22.12694-12697.2004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A03071 | - |
dc.relation.journalcode | J01930 | - |
dc.identifier.eissn | 1098-5514 | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.affiliatedAuthor | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | Lee, Jae Myun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 78 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 12694 | - |
dc.citation.endPage | 12697 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIROLOGY, Vol.78(22) : 12694-12697, 2004 | - |
dc.identifier.rimsid | 44552 | - |
dc.type.rims | ART | - |
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