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이소플라본 섭취가 전립선암환자의 serum PSA, 지질패턴, 항산화체계 및 면역체계에 미치는 영향

Other Titles
 The Effects of Isoflavone Supplementation on Serum PSA, Lipid Profile, Antioxidant and Immune System in Prostate Cancer Patients 
Authors
 이주민  ;  홍성준  ;  윤선  ;  이민준 
Citation
 Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지), Vol.33(8) : 1294-1301, 2004 
Journal Title
Journal of the Korean Society of Food Science and Nutrition(한국식품영양과학회지)
ISSN
 한국식품영양과학회지 
Issue Date
2004
Keywords
isoflavone ; prostate cancer ; prostate specific antigen (PSA) ; antioxidant status ; lipid profiles
Abstract
Soy foods are a unique dietary source of isoflavones, which have effects relevant to prostate cancer prevention. The present study determines the effects of a short-term isoflavone supplement on serum PSA (prostate specific antigen), lipid profile, antioxidant status, and immune system in prostate cancer patients. Ten prostate cancer patients were supplemented daily with 150 mg of isoflavone for 2 months. Blood samples were collected baseline and 2 month after for analysis of PSA, serum lipid profiles, total antioxidant status (TAS), grade of DNA damage in lymphocytes, IL-6, VEGF and TNF -α. After 2 month isoflavone supplementation, increased significantly a total of estimated urinary isoflavone excretion and did not change PSA. Serum lipid profiles showed significant change in serum total cholesterol level (p=0.007). However, there was no significant change in HDL- and LDL-cholesterol levels. TAS was increased but not significant after isoflavone supplementation. Tail moment (TM) was decreased and especially tail length (TL) was decreased significantly (p=0.043). IL-6 level was decreased but VEGF level and TNF -α level were increased. The results of the present study led to the conclusion that the isoflavone dosage (150 mg) in supplement had positive effects on the serum total cholesterol level and DNA damage.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112806
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