Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9

K Kim; H Nakagawa; W S El-Deiry; A K Rustgi; P Fei

doi:10.1038/sj.cdd.4401388

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Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9

Authors: K Kim ; H Nakagawa ; W S El-Deiry ; A K Rustgi ; P Fei

Citation: CELL DEATH AND DIFFERENTIATION, Vol.11(5) : 583-587, 2004

Journal Title: CELL DEATH AND DIFFERENTIATION

ISSN: 1350-9047

Issue Date: 2004

MeSH: Apoptosis/drug effects* ; Apoptosis Regulatory Proteins ; Caspase 9 ; Caspases/drug effects* ; Drug Therapy ; Epithelial Cells/drug effects ; Esophageal Neoplasms/drug therapy* ; Humans ; Membrane Glycoproteins/pharmacology* ; Proto-Oncogene Proteins c-bcl-2/metabolism* ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha/pharmacology* ; bcl-X Protein