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포상연부육종의 수술적 치료에 대한 고찰

Other Titles
 Surgical Treatment for the Alveolar Soft Part Sarcoma 
Authors
 안수민  ;  오정탁  ;  최승훈 
Citation
 JOURNAL OF THE KOREAN SURGICAL SOCIETY , Vol.66(1) : 50-55, 2004 
Journal Title
JOURNAL OF THE KOREAN SURGICAL SOCIETY (대한외과학회지)
ISSN
 1226-0053 
Issue Date
2004
Keywords
Alveolar soft part sarcoma ; Surgery ; Recurrence ; Metastasis
Abstract
Purpose: The aim of this study was to evaluate the clinicopathologic characteristics and the results of surgical treatment for alveolar soft part sarcoma (ASPS) Methods: The clinicopathologic characteristics and surgical treatment results were analyzed retrospectively by reviewing the medical records of 11 patients and interviewing them. Overall survival (OS) was calculated using the Kaplan-Meier method. Results: Of the 11 patients, 5 men and 13 women, the median age at diagnosis was 27 years and the mean tumor diameter was 6.0±1.9 cm. Six patients without distant metastasis at the time of diagnosis were treated with radical resection, and the other 5 with distant metastasis underwent palliative surgery or biopsy only, followed by chemo-radiation therapy. The onset of distant metastasis (40.0±13.5 months) was similar to the onset of local recurrence (43.3±22.4 months) after a radical operation. The most common site of metastasis was the lung, followed by the brain and bone. The median survival was 52 months and the 5-year OS was 27.2%. The 2-year OS in stage Ⅳ disease was 27.7%. The 5-year OS and the disease free survival among the patients with localized disease were 53.3% and 0%, respectively (P=0.043). Conclusion: Complete resection is the primary therapeutic option for ASPS. Close, long-term follow-up is recommended in order to detect recurrence, particularly in the lung, bone and brain. Long term survival can be achieved with aggressive surgery for local recurrence and even distant metastasis.
Files in This Item:
T200401641.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Jung Tak(오정탁)
Choi, Seung Hoon(최승훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112742
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