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Rosiglitazone 치료 후 adipocytokine 농도와 저밀도 근육량의 변화를 통한 인슐린 저항성의 개선정도

Other Titles
 The Effect of Rosiglitazone on Insulin Sensitivity Through Change of Concentrations of Adipocytokine and Low Density Muscle 
 남주영  ;  박종숙  ;  허갑범  ;  이현철  ;  임승길  ;  김경래  ;  안철우  ;  김똘미  ;  박진아  ;  조민호  ;  김철식 
 Journal of Korean Society for the Study of Obesity (대한비만학회지), Vol.13(2) : 110-120, 2004 
Journal Title
 Journal of Korean Society for the Study of Obesity  (대한비만학회지) 
Issue Date
Background: This study was to investigate the new mechanism of rosiglitazone in skeletal muscle to improve insulin resistance through relationship between concentrations of adipocytokine and mid thigh low density muscle area. Methods: Forty two type 2 diabetic patients (age: 32~70 years old, BMI 17.48~32.55 kg/m2, 15 women, 27 men) were enrolled in this study, and designed as rosiglitazone 4 mg, administered daily for 12 weeks. We assessed body composition, and measured the level of plasma adiponectin, leptin, resistin and various biochemical parameters. Results: Twelve weeks of 4 mg/day rosiglitazone treatment improved insulin resistance (IR, as measured using the Kitt: from 2.52 0.98 to 2.85 1.11%/min, p<0.05). Plasma adiponectin levels increased from 5.58 2.19 to 8.80 3.02 g/mL (p<0.01). Plasma leptin levels decreased but did not change significantly (7.47 6.44 to 6.63 4.06 pg/mL, p=0.10). Plasma resistin levels decreased from 3.23 2.46 to 1.91 1.93 g/mL (p<0.01). Cross sectional area of low density muscle (LDM) at the mid thigh was positively correlated with insulin resistance. However any concentration of adipocytokines we measured was not associated with insulin resistance in this study. Conclusion: We found that improvement of insulin resistance by rosiglitazone treatment was not associated with change of mid thigh low density muscle and concentrations of adipocytokines. We should consider that our subjects were relatively well obese and their insulin resistance was not severe. We also postulated that other factor rather than accumulation of fatty acid metabolite in skeletal muscle may be much more important in regard to change of insulin resistance with rosiglitazone treatment. It is also possible the effects of rosiglitazone on low density muscle may be different in Korean patients with type 2 DM.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김경래(Kim, Kyung Rae)
김똘미(Kim, Dol Mi)
김철식(Kim, Chul Sik)
남주영(Nam, Ju Young)
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
박진아(Park, Jina)
안철우(Ahn, Chul Woo)
이현철(Lee, Hyun Chul)
임승길(Lim, Sung Kil)
허갑범(Huh, Kap Bum)
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