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만성 B형 간염의 바이러스 유전자형과 라미부딘 내성 돌연변이 및 조직학적 연관성

Other Titles
 Virus Genotype and Lamivudine Resistant Mutation in Chronic B-Viral Hepatitis andCorrelation with Pathologic Findings 
Authors
 신정원  ;  박기현  ;  이동화  ;  이상규  ;  김문정  ;  김진  ;  김연수  ;  박노진  ;  전병열  ;  김미영  ;  진소영  ;  최태윤 
Citation
 KOREAN JOURNAL OF LABORATORY MEDICINE , Vol.24(3) : 198-202, 2004 
Journal Title
 KOREAN JOURNAL OF LABORATORY MEDICINE 
ISSN
 1598-6535 
Issue Date
2004
Keywords
HBV genotyping ; Lamivudine resistant mutation ; Histologic grade and stage
Abstract
Background : Despite significant progress in vaccine and therapeutic regimen, hepatitis B virus (HBV) infection remains one of the major diseases. Long-term use of lamivudine can induce the emer¬gence of drug resistance. TRUGENE™ HBV Genotyping (Visible Genetics Inc.. Ga, USA) is an assay that reports the viral genotype and mutations likely to confer resistance to antiviral therapy. In this study, we analyzed HBV genotype and mutations and correlated them with the histologic grade and stage of the liver disease to provide the useful information about the therapy of chronic liver disease. Methods :HBV DNA was isolated from 86 patients with HBV-associated chronic liver diseases and analyzed by TRUGENE™ HBV Genotyping. Histologic grade and stage were correlated with the mutations. Results : HBV genotypes of 86 patients were all C (100%). Mutations associated with lamivudine resistance were detected in 10 patients (11.6%) and M2041 (YIDD) mutant was the most common. Unknown mutation such as L180F was also detected. Statistical analysis showed that the number of coding changes at HBsAg region was significantly correlated with the lobular activity (P=0.01). Conclusions :All patients were genotype C and lamivudine resistant mutations were detected in 11.6%. L18OF mutation, not known previously, was detected in one case. Number of coding changes at HBsAg region was significantly correlated with the lobular activity. It was considered that follow-up studies about the clinical significance of coding changes in HBsAg are needed, and that a further study such as in vitro transfection is necessary to confirm the possibility of a novel mutation of Ll 80F.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112688
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