Cited 54 times in
γδ T Cells in Immunity Induced by Mycobacterium bovis Bacillus Calmette-Guérin Vaccination
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-07-14T17:19:17Z | - |
dc.date.available | 2015-07-14T17:19:17Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112647 | - |
dc.description.abstract | Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination is efficacious for newborns or adults with no previous exposure to environmental mycobacteria. To determine the relative contribution and the nature of γδ T-cell receptor-positive T cells in newborns, compared to CD4+ T cells, in immunity induced by M. bovis BCG vaccination, 4-week-old specific-pathogen-free pigs were vaccinated with M. bovis BCG and monitored by following the γδ T-cell immune responses. A flow cytometry-based proliferation assay and intracellular staining for gamma interferon (IFN-γ) were used to examine γδ T-cell responses. Pigs were found to mount Th1-like responses to M. bovis BCG vaccination as determined by immunoproliferation and IFN-γ production. The γδ T-cell lymphoproliferation and IFN-γ production to stimulation with mycobacterial antigens were significantly enhanced by M. bovis BCG vaccination. The relative number of proliferating γδ T cells after stimulating peripheral blood mononuclear cells with Mycobacterium tuberculosis H37Rv culture filtrate protein was higher than that of CD4+ T cells at an early time point after M. bovis BCG vaccination, but CD4+ T cells were found to be more abundant at a later time point. Although the γδ T-cell responses were dependent on the presence of CD4+ T cells for the cytokine interleukin-2, the enhanced γδ T cells were due to the intrinsic changes of γδ T cells caused by M. bovis BCG vaccination rather than being due solely to help from CD4+ T cells. Our study shows that γδ T cells from pigs at early ages are functionally enhanced by M. bovis BCG vaccination and suggests an important role for this T-cell subset in acquired immunity conferred by M. bovis BCG vaccination. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1504~1511 | - |
dc.relation.isPartOf | INFECTION AND IMMUNITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Antigens, Bacterial/administration & dosage | - |
dc.subject.MESH | BCG Vaccine/immunology | - |
dc.subject.MESH | BCG Vaccine/pharmacology* | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Interferon-gamma/biosynthesis | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, gamma-delta/metabolism* | - |
dc.subject.MESH | Sus scrofa | - |
dc.subject.MESH | T-Lymphocyte Subsets/immunology* | - |
dc.title | γδ T Cells in Immunity Induced by Mycobacterium bovis Bacillus Calmette-Guérin Vaccination | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Jinhee Lee | - |
dc.contributor.googleauthor | Keumhwa Choi | - |
dc.contributor.googleauthor | Thomas W. Molitor | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Michael R. Olin | - |
dc.identifier.doi | 10.1128/IAI.72.3.1504-1511.2004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01055 | - |
dc.identifier.eissn | 1098-5522 | - |
dc.identifier.pmid | 14977956 | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 72 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1504 | - |
dc.citation.endPage | 1511 | - |
dc.identifier.bibliographicCitation | INFECTION AND IMMUNITY, Vol.72(3) : 1504-1511, 2004 | - |
dc.identifier.rimsid | 57800 | - |
dc.type.rims | ART | - |
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