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Gene and Cell Replacement via Neural Stem Cells

 Hyoung Tai Kim  ;  Il Sun Kim  ;  Kook In Park  ;  Il Shin Lee  ;  Seung Eun Lim 
 Yonsei Medical Journal, Vol.45(Suppl.) : 32-40, 2004 
Journal Title
 Yonsei Medical Journal 
Issue Date
Animals ; Gene Transfer Techniques ; Genetic Therapy/methods* ; Humans ; Nerve Tissue/cytology* ; Stem Cell Transplantation* ; Stem Cells/metabolism* ; Stem Cells/physiology
Neural stem cells ; cell replacement ; gene therapy ; neurologic disorders
Neural stem cells (NSCs) are operationally defined by their ability to self-renew, to differentiate into cells of all glial and neuronal lineages throughout the neuraxis, and to populate developing or degenerating central nervous system (CNS) regions. Thus their use as graft material can be considered analogous to hematopoietic stem cell-mediated reconstitution and gene transfer. The recognition that NSCs propagated in culture could be reimplanted into mammalian brain, where they might integrate appropriately throughout the mammalian CNS and stably express foreign genes, has unveiled a new role for neural transplantation and gene therapy and a possible strategy for addressing the CNS manifestations of diseases that heretofore had been refractory to intervention. NSCs additionally have the appealing ability to home in on pathology, even over great distances. Such observations help to advance the idea that NSCs - as a prototype for stem cells from other solid organs - might aid in reconstructing the molecular and cellular milieu of maldeveloped or damaged CNS.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Il-Sun(김일선) ORCID logo https://orcid.org/0000-0003-4033-4323
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
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