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Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice

Authors
 Kyong Min Choi  ;  Dae Hwan Hwang  ;  Dong Soo Kim  ;  Do-Young Yoon  ;  Kyung Mi Shin 
Citation
 Korean Journal of Pediatrics, Vol.47(6) : 677-684, 2004 
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Issue Date
2004
Keywords
Flavon ; Artemisia absinthium ; Collagen induced arthritis ; IL-10 ; TNF-α
Abstract
PURPOSE: In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated.0aMETHODS: DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies and a stimulation index of the splenocytes of the mice were measured. IL-10 and TNF-alpha in the supernatants of the mice sera were measured by ELISA. mRNA expression for IL-10 and TNF-alpha in the splenocytes were tested.0aRESULTS: Flavon extracted from Artemisia absinthium appears to be an effective suppressor of CIA in mice. The serum anti-collagen antibody level and stimulation index of the cultured splenocytes showed no significant differences among the three experimental groups. Also serum IL-10 and TNF-alpha levels did not show any significant differences among the three experimental groups. An increased expression of mRNA for IL-10 was observed in the splenocytes treated with flavon.0aCONCLUSION: With these results, flavon extracted from Artemisia absinthium appears to have a suppressive effect of CIA. The mechanism of the suppressive effect of flavon extracted from Artemisia absinthium may be from a stimulation of IL-10 production.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Sin, Kyoung Mi(신경미)
Choi, Kyong Min(최경민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112481
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