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폐동맥고혈압 진단에 있어 N-terminal Pro-brain Natriuretic Peptide 측정의 유용성

Other Titles
 The Utility of Measurement of Plasma N-terminal Pre-brain Natriuretic Peptide in Diagnosis of Pulmonary Hypertension 
Authors
 한창훈  ;  강석민  ;  김성규  ;  심원흠  ;  장준  ;  김세규  ;  김영삼  ;  정재호  ;  박무석  ;  이중민  ;  황상연  ;  조재희  ;  문진욱 
Citation
 TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.56(1) : 67-76, 2004 
Journal Title
 TUBERCULOSIS AND RESPIRATORY DISEASES 
ISSN
 1738-3536 
Issue Date
2004
Keywords
N-terminal pro-brain natriuretic peptide ; Pulmonary hypertension ; Echocardiography
Abstract
Background : Pulmonary hypertension is a poor prognostic factor in patients with chronic respiratory disease. However, diagnosing pulmonary hypertension is a difficult procedure which often requires an invasive test. Thus new alternative biochemical markers would be useful in clinical field and are in search. We sought to assess the role of plasma N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with pulmonary hypertension. Materials and Methods : We measured plasma NT-proBNP level in twenty nine patients suspected for pulmonary hypertension. Pulmonary hypertension was defined as being right ventricular systolic pressure more than 35 mm Hg estimated by Doppler echocardiography. Plasma NT-proBNP level was measured by electrochemiluminescence sandwich immunoassay. Results : The log-transformed values for plasma NT-proBNP levels showed a linear correlation (correlation coefficiency: 0.783, p-value <0.001) with right ventricular systolic pressure. Plasma NT-proBNP levels closely correlated with right ventricular systolic pressure, right ventricular hypertrophy, interventricular septal flattening and right ventricular dilatation. Conclusion : Our results suggest that the measurement of plasma NT-proBNP level is an useful marker of the presence of pulmonary hypertension.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Sung Kyu(김성규)
Kim, Se Kyu(김세규)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Moon, Jin Wook(문진욱)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Shim, Won Heum(심원흠)
Lee, Jung Min(이중민)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Chung, Jae Ho(정재호)
Cho, Jae Hee(조재희)
Hahn, Chang Hoon(한창훈)
Hwang, Sang Yon(황상연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112370
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