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판막질환자에서 폐동맥압이 norepinephrine의 점적주입에 따른 우심실 기능 변화에 미치는 영향

Other Titles
 Effect of Pulmonary Artery Pressure on Changes in Right Ventricular Function according to Norepinephrine Infusion in Patients with Valvular Heart Disease 
 곽영란  ;  김종엽  ;  방서욱  ;  이강훈  ;  이종화  ;  오영준  ;  김승호 
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.47(6) : 824-829, 2004 
Journal Title
Issue Date
chronic pulmonary hypertension ; norepinephrine ; right ventricular function
BACKGROUND: Increasing coronary perfusion pressure by using a vasopressor is one of the important treatment strategies in pulmonary hypertension. In present study, we evaluated whether chronic pulmonary hypertension influences the effect of norepinephrine (NE) on right ventricular function and hemodynamic variables in patients with valvular heart disease. METHODS: Forty eight patients undergoing valve replacement surgery were divided into two groups according to pulmonary artery pressure, i.e., a control (n = 28) and a pulmonary hypertension group (n = 20). A thermodilution pulmonary artery catheter for continuous monitoring of cardiac output, right ventricular (RV) ejection fraction and RV volume was inserted before the induction of anesthesia. When systemic hypotension occurred following induction of anesthesia, norepinephrine was infused at rates of 0.03 and then 0.06µg/kg/min for 10 minutes, respectively and hemodynamic variables were measured after anesthesia induction, and at the end point of each infusion rate. RESULTS: No significant differences occurred in systemic or pulmonary hemodynamic variables according to the infusion of norepinephrine between the two groups. And, no significant changes were observed in right ventricular performance according to the infusion of norepinephrine in two groups. CONCLUSIONS: Norepinephrine did not show different systemic or pulmonary hemodynamic effects in patients with or without chronic pulmonary hypertension. Norepinephrine did not increase the right ventricular ejection fractions or cardiac outputs of patients with chronic pulmonary hypertension.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kim, Seung Ho(김승호)
Bang, Sou Ouk(방서욱)
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Lee, Jong Wha(이종화)
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