Serial Follow-up of Neuroimaging Findings in a Progression-free Survival Case with Progressive Multifocal Leukoencephalopathy in Nonimmunocompromised Child
Authors
도원영 ; 조양제 ; 최중언 ; 선우일남 ; 김태승 ; 김동수 ; 이종두 ; 박수철
Citation
Journal of the Korean Neurological Association, Vol.22(5) : 524-528, 2004
Progressive multifocal leukoencephalopathy (PML) is a demyelination disease caused by opportunistic infection of the ubiquitous, usually nonpathogenic neurotropic papovavirus (JC virus). The virus infects and destroys myelin-producing oligodendrocytes, thereby causing patchy areas of demyelination in the cerebral white matter. It is exclusively a disease of immunosuppressed individuals. We report a case of an immunocompetent child patient with pathologically-proven PML and with a survival over 3 years after diagnosis. Serial follow up of neuroimaging study including brain MRI, MRS, SPECT and PET was obtained.