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자궁경부 상피내종양 환자에서 외과적 절제술이 인유두종 바이러스 감염 추이에 미치는 영향

Other Titles
 Effect of Surgical Therapy on the Courses of Human Papillomavirus Infectionin Cervical Intraepithelial Neoplasia 
 노진래  ;  김재욱  ;  김건홍  ;  김성훈  ;  김영태 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.47(3) : 451-457, 2004 
Journal Title
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) 
Issue Date
Human papillomavirus (HPV) ; Cervical intraepithelial neoplasia (CIN) ; HPV DNA genotyping ; Surgical therapy
Objective : To investigate whether human papillomavirus (HPV) associated with cervical intraepithelial neoplasia was successfully eliminated after surgical therapy such loop excision of transformation zone (LLETZ) or type I extended hysterectomy. Methods L Seventy four cervical intraepithelial neoplasia (CIN) patients with HPV infection who were admitted for LLETZ or type I extended hysterectomy were recruited into this prospective study. HPV infection was confirmed by HPV DNA genotyping using HPV DNA Chip (Biomedlab, Seoul, Korea) before and after surgical therapy. Results : According to the assay used (HPV DNA Chip^(?)) at the postoperative visit, 82.5% of treated patients were completely free from HPV infection. And there was no statistical difference between LLETZ and type I extended hysterectomy (p=0.452). However, there was persistent infection in 17.5% of treated patients after final surgical therapy. Conclusion : Although the HPV infection associated with CIN was effectively eliminated after LLETZ and type I extended hysterectomy, there was persistent infection in 17.5% of treated patients. Therefore, the careful followed-up examination of HPV infection should be taken in these patients.
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1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kun Hong(김건홍) ORCID logo https://orcid.org/0000-0001-5639-6372
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
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