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악성 흉막액에서 CEA와 CYFRA 21-1의 진단적 유용성

Other Titles
 Diagnostic Utility of Pleural Fluid CEA and CYFRA 21-1 for Malignant Pleural Effusions 
 정재호  ;  최정은  ;  김세규  ;  김성규  ;  김주항  ;  장준  ;  김영삼  ;  문진욱  ;  황상연  ;  박무석 
 Tuberculosis and Respiratory Diseases, Vol.57(1) : 32-36, 2004 
Journal Title
 Tuberculosis and Respiratory Diseases 
Issue Date
Background : The purpose of this study was to evaluate the usefulness of the pleural fluid carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1) tumor markers as complementary tools for the diagnosis of malignant pleural effusions. Patients and Methods : The levels of pleural and serum CEA and CYFRA 21-1 were prospectively assayed in 222 patients with pleural effusions (150 benign effusions, 57 bronchogenic carcinomas and 15 metastatic carcinomas). Results : The levels of pleural fluid CEA and CYFRA 21-1 in the malignant effusions were significantly higher than those in the benign effusions. With a specificity of 95%, the cut off values for the CEA and CYFRA 21-1 in pleural effusions were 5 and 89 ng/ml, respectively. The diagnostic sensitivities of the pleural fluid CEA and CYFRA 21-1 in malignant effusions were 72 and 54%, respectively, whereas using a combination of the two, the sensitivity increased to 87% (p<0.05). Conclusions : These findings suggest that a combination of the pleural fluid CEA and CYFRA 21-1 in pleural effusions can be useful in the diagnosis of malignant pleural effusions.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김성규(Kim, Sung Kyu)
김세규(Kim, Se Kyu)
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
김주항(Kim, Joo Hang)
문진욱(Moon, Jin Wook)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
정재호(Chung, Jae Ho)
황상연(Hwang, Sang Yon)
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