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성인 아토피피부염 환자에서 Narrow-band Ultraviolet B의 치료 효과

Other Titles
 Clinical Improvement and Laboratory Parameters after Narrow-band Ultraviolet B Phototherapy in Adult Atopic Dermatitis Patients 
 정지인  ;  이주희  ;  이광훈 
 Korean Journal of InvestigativeDermatology (대한피부연구학회지), Vol.11(2) : 57-66, 2004 
Journal Title
 Korean Journal of InvestigativeDermatology (대한피부연구학회지) 
Issue Date
Atopic dermatitis ; Narrow-band ultraviolet B ; Eosinophilic cationic protein ; E-selectin ; Phototherapy
The increasing incidence of atopic dermatitis calls for attention on new therapeutic modalities such as phototherapy. Adverse outcomes following the continuous uses of corticosteroid and immunosuppressive agents could be avoided with the narrow-band ultraviolet B phototherapy. We aimed to assess the effects of narrow-band ultraviolet B phototherapy for adult atopic dermatitis patients with moderate to severe disease. We have conducted an uncontrolled study on 24 adult atopic dermatitis patients with moderate to severe disease. Laboratory data including eosinophil fraction, serum levels of eosinophilic cationic protein and soluble E-selectin that support the atopic inflammation were compared before and after the 12 week treatment session, as well as the clinical parameters assessed by eczema area severity index and patient questionnaires. Patients showed clinical improvement and serum eosinophilic fraction and E-selectin level showed significant decrements following the phototherapy. The improvements evidenced by clinical and laboratory data seem to be promising. Narrow-band ultraviolet B phototherapy may be an useful method for the treatment of adult atopic dermatitis patients with moderate to severe disease with fewer side effects.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hoon(이광훈)
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
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