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비만하지 않은 한국인 성인 제2형 당뇨병 환자의 항GAD 항체 양성률과 항체 유무에 따른 임상적, 생화학적 특성

Other Titles
 The Frequency of Anti-GAD Antibody in Non-obese, Adult-onset Type 2 Diabetes in Korea and Clinical and Biological Characteristics According to Anti-GAD Antibody 
Authors
 김철식  ;  박진아  ;  이현철  ;  김경래  ;  임승길  ;  차봉수  ;  암철우  ;  김똘미  ;  남주영  ;  박종숙  ;  조민호 
Citation
 Journal of Korean Diabetes Association (당뇨병), Vol.28(2) : 66-74, 2004 
Journal Title
 Journal of Korean Diabetes Association  (당뇨병) 
ISSN
 1015-6461 
Issue Date
2004
Abstract
Background: Some of the characteristic features of diabetes mellitus in Korea are that 70-80% of patients are non-obese or adult-onset type, and type 1 diabetes is very rare. Occasionally, autoantibodies to glutamic acid decarboxylase(GAD) are found in typical, type 2 diabetes mellitus patients(T2DM). The role of the autoantibody to GAD in T2DM is unknown. The aim of this study was to determine the clinical and biochemical characteristics between GAD-positive and GAD-negative non-obese, adult-onset diabetics in Korea. Methods: A cohort of 428 type 2 diabetes patients was included. The measured autoantibodies to GAD were measured, and the C-peptide and HbA1c levels, anthropometric data(weight, height, body mass index and waist circumference), blood pressure and lipid profiles compared between the two groups. Results: Compared to the antibody-negative group(n=374; 87.4%), patients with the anti-GAD antibody(n=54; 12.6%) had significantly lower C-peptide levels and were significantly younger. The anti GAD-positive group had a lower BMI, more frequently needed insulin supplements, and a lower prevalence of hypertension. There were no significant differences in gender and family history of diabetes between the two groups. Conclusion: The presence of the autoantibody to GAD allowed the group with more deteriorated beta-cell function and more frequent need for insulin supplements, but a lower prevalence of obesity and hypertension to be determined.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김경래(Kim, Kyung Rae)
김똘미(Kim, Dol Mi)
김철식(Kim, Chul Sik)
남주영(Nam, Ju Young)
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
박진아(Park, Jina)
안철우(Ahn, Chul Woo)
이현철(Lee, Hyun Chul)
임승길(Lim, Sung Kil)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112003
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