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미세 혈관 감압술 후 청력 손실에 대한 thiopental sodium의 효과

Other Titles
 Effect of Thiopental Sodium on Hearing Outcomes Following Microvascular Decompression Surgery 
 김원주  ;  김종훈  ;  민경태  ;  이윤창  ;  배선준 
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.47(5) : 617-622, 2004 
Journal Title
Issue Date
brainstem auditory evoked potentials ; microvascular decompression ; sensorineural hearing loss ; thiopental sodium
BACKGROUND: The use of intraoperative brainstem auditory evoked potential (BAEP) has reduced the incidence of sensorineural hearing loss (SNHL) after microvascular decompression (MVD). This complication occurs due to direct compressive and/or stretching injury of the cochlear nerve or to indirect compression of the perineural vasculature during cerebellar retraction. The aim of this study was to evaluate the effect of thiopental sodium on SNHL after MVD for hemifacial spasm. METHODS: 94 hemifacial spasm patients with normal hearing function preoperatively and who underwent MVD under intraoperative BAEP monitoring were enrolled in this study. Patients were randomly divided into two groups. 52 patients were administered placebo (control group) and 42 patients were administered thiopental sodium 5 mg/kg intravenously 5 minutes before cerebellar retraction (thiopental group). The effects of thiopental on intraoperative BAEP changes and postoperative hearing functional outcomes were sought. Incidence and degree of postoperative SNHL were evaluated by pure tone audiometry threshold analysis. RESULTS: Maximal changes in intraoperative BAEP parameters did not differ between the two groups, and neither did the incidence nor degree of SNHL. In the control group, 4 transient and 4 permanent postoperative SNHL, including 2 deaf patients, occurred with an overall incidence of 15.4%. In the thiopental group, 2 transient and 1 permanent postoperative SNHL occurred, with an overall incidence of 7.1%. CONCLUSIONS: Thiopental sodium administered prior to cerebellar retraction might reduce the incidence of postoperative hearing loss.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ju(김원주)
Kim, Jong Hoon(김종훈)
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Yoon Chang(이윤창)
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