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대퇴골두 무혈성괴사 동물모델에서 혈관내피성장인자의 발현

Other Titles
 Expression of Vascular Endothelial Growth Factor in an Animal Model of Avascular Necrosis of the Femoral Head 
Authors
 양익환  ;  김성훈  ;  김현우  ;  박희완  ;  한수봉  ;  양규현  ;  주선영  ;  공선영 
Citation
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지), Vol.7(2) : 115-124, 2004 
Journal Title
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지) 
ISSN
 1226-8933 
Issue Date
2004
Keywords
VEGF ; Apoptosis ; Growth plate ; Spontaneously Hypertensive Rats
Abstract
Purpose: To evaluate the pathologic changes, apoptosis of chondrocytes, and expression pattern of vascular endothelial growth factor (VEGF) in the growth plate of Spontaneouly Hypertensive Rats (SHR). Materials and Methods: Sixty SHRs and thirty Wister Kyoto rats(control, WKYs) were sacrificed at the age of 6, 9, 12, 15 and 18 weeks. SHRs were divided into the groups of [SHR-n] and [SHR+n] according to the evidence of ischemic necrosis of the femoral head. TUNEL assay was done for the investigation of apoptotic changes in the growth plate. VEGF immunohistochemistry was performed to identify the expression of VEGF in the growth plate, epiphysis, and articular cartilage. Results: Apoptosis of growth plate in the groups of SHR was more evident than that of WKY group. VEGF expression in the articular cartilage, epiphysis and growth plate was decreased in the course of normal ossification. VEGF expression in the epiphysis and growth plate was decreased in the groups of SHR, especially in the group of [SHR+n]. Normal expression was found in the articular cartilage of all three groups. Conclusion: VEGF was expressed in the growth-dependent manner, and is an essential factor for the longitudinal growth of growth plate and normal ossification.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Hun(김성훈)
Kim, Hyun Woo(김현우) ORCID logo https://orcid.org/0000-0001-8576-1877
Park, Hui Wan(박희완)
Yang, Kyu Hyun(양규현) ORCID logo https://orcid.org/0000-0001-7183-588X
Yang, Ick Hwan(양익환)
Hahn, Soo Bong(한수봉)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111919
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