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노인에서 IGFBP-3 promoter polymorphism이 제2형 당뇨병에 미치는 영향

Other Titles
 Implication of IGFBP-3 Promoter Polymorphism in Type 2 DM in Elderly 
 박종숙  ;  남주영  ;  이현철  ;  김경래  ;  임승길  ;  차봉수  ;  안철우  ;  박진아  ;  조민호  ;  김똘미  ;  김철식 
 Korean Journal of Clinical Geriatrics (임상노인의학회지), Vol.5(2) : 216-222, 2004 
Journal Title
 Korean Journal of Clinical Geriatrics  (임상노인의학회지) 
Issue Date
Background: Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is a major determinant of circulating levels of the IGFs and is clinically useful for the evaluation of GH deficiency and for predicting the response to GH treatment. Circulating levels of IGF-1 and IGFBP-3 vary considerably among individuals and have been implicated in various medical conditions. We investigated the IGFBP-3 genotype distribution in Korean elderly and relations between IGFBP-3 promoter -202 locus A/C polymorphism and medical conditions. Methods: Single nucleotide polymorphism at the -202 locus of the IGFBP-3 promoter was genotyped for 100 samples from a study population who is older than 60 years. Results: The frequency of each polymorphic variation at the -202 locus in these study population was AA=43 (43%), AC=48 (48%), and CC=8 (8%). In both genders, the subjects with the CC genotype were taller, whereas those with AC genotype had higher weight, BMI and BSA comparing those with the other genotypes, but these facts did not reach statistical significance. The prevalence of type 2 DM and the mean fasting blood glucose level did not differ among genotypes in the female gender. In the male population, however, the prevalence of type 2 DM was higher in the subjects with the AC genotype (P=0.016) which is reflected by the elevated mean fasting glucose level (P=0.106). Conclusion: IGFBP-3 promoter -202 locus A/C polymorphism, which reflects its serum level and further implicates IGFs bioactivity, was associated with a higher prevalence of type 2 DM in the male gender, suggesting IGFBP-3 might play a role in blood glucose homeostasis.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김경래(Kim, Kyung Rae)
김똘미(Kim, Dol Mi)
김철식(Kim, Chul Sik)
남주영(Nam, Ju Young)
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
박진아(Park, Jina)
안철우(Ahn, Chul Woo)
이현철(Lee, Hyun Chul)
임승길(Lim, Sung Kil)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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