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과민성 장증후군 환자에서 세로토닌 수송단백질 유전자의 다형성과 혈중 세로토닌치간의 연관 관계

Other Titles
 Serotonin Transporter Gene Polymorphism and its Relationship to Plasma Serotonin in Irritable Bowel Syndrome 
Authors
 박효진  ;  이덕용  ;  이상인  ;  지상원  ;  김영균  ;  최은주  ;  김민수 
Citation
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지), Vol.10(2) : 125-129, 2004 
Journal Title
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지) 
ISSN
 1226-5608 
Issue Date
2004
Keywords
Irritable bowel syndrome ; Serotonin ; Serotonin transporter protein
Abstract
Background/Aims: Serotonin is an important mediator of intestinal peristalsis and it undergoes reuptake by a transporter protein (SERT). It has been reported that polymorphisms in the promoter for synthesis of SERT (SERT-P) influence the response to a serotonin reuptake inhibitor and a serotonin receptor antagonist. The aim of this study was to investigate gene polymorphism in the SERT-P in healthy adults and patients with irritable bowel syndrome (IBS) and a plasma serotonin level according to genetic polymorphism. Methods: SERT gene polymorphism was assessed by polymerase chain reaction on DNA chains in serum samples from 53 patients with IBS and 56 healthy adults. The platelet-depleted plasma serotonin level of a fasting state was quantitatively measured by ELISA. Results: There was no significant difference in the allele frequency between the IBS and the control group, and according to the subtypes of IBS patients. The platelet-depleted plasma serotonin level was significantly higher in IBS patients than in controls (P<0.05). However, there was no significant difference in the plasma serotonin level according to the subtypes of IBS or genetic polymorphism of SERT-P. Conclusions: SERT-P is not a key factor in determining the development of IBS in Korea. Patients with IBS have significantly higher fasting plasma serotonin levels than controls, irrespective of genetic polymorphism at SERT-P.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Gyun(김영균)
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Sang In(이상인)
Ji, Sang Won(지상원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111821
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