Cited 40 times in
Death effectors of beta-cell apoptosis in type 1 diabetes
DC Field | Value | Language |
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dc.contributor.author | 장인익 | - |
dc.date.accessioned | 2015-07-14T16:50:53Z | - |
dc.date.available | 2015-07-14T16:50:53Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1096-7192 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111709 | - |
dc.description.abstract | While it is generally agreed that apoptosis of pancreatic beta-cells is the most important and final step in the progression of type 1 diabetes without which clinical diabetes does not develop, it has not been elucidated which molecule(s) are the real culprit(s) in type 1 diabetes. Perforin, FasL, TNFalpha, IL-1, IFNgamma, and NO have been claimed as the effector molecules; however, they, as a single agent, might explain only part of beta-cell death in type 1 diabetes. While FasL was initially considered as a strong candidate for the most important death effector, following experiments cast doubt on such a hypothesis. Combinations or synergism between IFNgamma and TNFalpha or IL-1beta are being revisited as the death effectors, and molecular mechanism explaining such a synergism was addressed in several recent papers. The role of NF-kappaB for pancreatic beta-cell death in type 1 diabetes is also controversial. While NF-kappaB plays anti-apoptotic roles in most other death models, its role in type 1 diabetes might be different probably due to the involvement of multiple cytokines at different stages of the disease progression and the peculiarity of pancreatic beta-cells. Recent papers also suggested a role for Ca2+ in cytokine-mediated pancreatic beta-cell death. Such participation of Ca2+ in beta-cell death appears to have a close relevance to the mitochondrial events or ER stress that constitutes an important part of cell death machinery recently identified. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 82~92 | - |
dc.relation.isPartOf | MOLECULAR GENETICS AND METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/physiology* | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/metabolism | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/pathology* | - |
dc.subject.MESH | Fas Ligand Protein | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/metabolism | - |
dc.subject.MESH | Interleukin-1/metabolism | - |
dc.subject.MESH | Islets of Langerhans/metabolism* | - |
dc.subject.MESH | Islets of Langerhans/pathology* | - |
dc.subject.MESH | Membrane Glycoproteins/metabolism | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Nitric Oxide/metabolism | - |
dc.subject.MESH | Perforin | - |
dc.subject.MESH | Pore Forming Cytotoxic Proteins | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/physiology | - |
dc.title | Death effectors of beta-cell apoptosis in type 1 diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Myung-Shik Lee | - |
dc.contributor.googleauthor | Inik Chang | - |
dc.contributor.googleauthor | Sunshin Kim | - |
dc.identifier.doi | 10.1016/j.ymgme.2004.08.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02258 | - |
dc.identifier.eissn | 1096-7206 | - |
dc.identifier.pmid | 15464423 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1096719204002094 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Diabetes | - |
dc.subject.keyword | Cytokines | - |
dc.subject.keyword | Synergism | - |
dc.subject.keyword | Calcium | - |
dc.contributor.alternativeName | Chang, In Ik | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 83 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 82 | - |
dc.citation.endPage | 92 | - |
dc.identifier.bibliographicCitation | MOLECULAR GENETICS AND METABOLISM, Vol.83(1-2) : 82-92, 2004 | - |
dc.identifier.rimsid | 37426 | - |
dc.type.rims | ART | - |
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