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Crossed-withdrawal reflex in a rat model of neuropathic pain: implications in neural plasticity

Authors
 Ran Won  ;  Se Jung Jung  ;  Bae Hwan Lee  ;  Sang Sup Chung  ;  Yong Gou Park 
Citation
 NEUROSCIENCE LETTERS, Vol.369(3) : 239-244, 2004 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2004
MeSH
Action Potentials/physiology ; Action Potentials/radiation effects ; Animals ; Disease Models, Animal ; Functional Laterality/physiology* ; Male ; Neuralgia/etiology ; Neuralgia/physiopathology* ; Neuronal Plasticity/physiology* ; Pain Measurement/methods ; Physical Stimulation/methods ; Rats ; Rats, Sprague-Dawley ; Reflex/physiology* ; Sciatic Neuropathy/complications ; Sciatic Neuropathy/physiopathology* ; Time Factors
Keywords
Nerve injury ; Rat ; Allodynia ; Mirror image pain ; Crossed-withdrawal reflex
Abstract
Recently we developed a neuropathic rat model employing a distal sciatic nerve branch injury, in which rats show vigorous behavioral signs of neuropathic pain. This study was performed to evaluate the crossed-withdrawal reflex in which any stimuli applied to the uninjured side produces allodynic signs on the injured side in our neuropathic pain model. Rats that received neuropathic surgery developed behavioral signs of neuropathic pain. In addition, these rats developed pain responses of the injured paw to stimuli applied to the contralateral uninjured paw, therefore, demonstrating ‘the crossed-withdrawal reflex.’ Moreover, electrical stimulation of the uninjured paw developed evoked potentials in the ventral root on the injured side. These results suggest that information processing from input on the uninjured side to output on the injured side, can be facilitated in rats with a nerve injury and that neuroplasticity may contribute to the crossed-withdrawal reflex.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394004009917
DOI
10.1016/j.neulet.2004.07.096
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111648
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