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Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

DC Field Value Language
dc.contributor.author이종은-
dc.date.accessioned2015-07-14T16:48:52Z-
dc.date.available2015-07-14T16:48:52Z-
dc.date.issued2004-
dc.identifier.issn0169-328X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111643-
dc.description.abstractWhen intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.-
dc.description.statementOfResponsibilityopen-
dc.format.extent146~149-
dc.relation.isPartOfMOLECULAR BRAIN RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis*-
dc.subject.MESHBlotting, Western/methods-
dc.subject.MESHBrain/cytology-
dc.subject.MESHBrain/drug effects*-
dc.subject.MESHBrain-Derived Neurotrophic Factor/pharmacology*-
dc.subject.MESHCaspase 12-
dc.subject.MESHCaspase 3-
dc.subject.MESHCaspases/metabolism-
dc.subject.MESHDrug Interactions-
dc.subject.MESHGlial Cell Line-Derived Neurotrophic Factor-
dc.subject.MESHIn Situ Nick-End Labeling/methods-
dc.subject.MESHMale-
dc.subject.MESHNerve Growth Factors/pharmacology*-
dc.subject.MESHOrganometallic Compounds/antagonists & inhibitors-
dc.subject.MESHOrganometallic Compounds/toxicity*-
dc.subject.MESHPyrones/antagonists & inhibitors-
dc.subject.MESHPyrones/toxicity*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.titleOpposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorSeung-Ju Yang-
dc.contributor.googleauthorJong Eun Lee-
dc.contributor.googleauthorSung-Woo Cho-
dc.contributor.googleauthorSoo Young Choi-
dc.contributor.googleauthorJae-Wan Huh-
dc.contributor.googleauthorKwan Ho Lee-
dc.identifier.doi10.1016/j.molbrainres.2004.05.016-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02252-
dc.identifier.pmid15306132-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0169328X04002347-
dc.subject.keywordAluminum-
dc.subject.keywordApoptosis-
dc.subject.keywordGDNF-
dc.subject.keywordBDNF-
dc.subject.keywordCaspase-3-
dc.subject.keywordCaspase-12-
dc.contributor.alternativeNameLee, Jong Eun-
dc.rights.accessRightsnot free-
dc.citation.volume127-
dc.citation.number1-2-
dc.citation.startPage146-
dc.citation.endPage149-
dc.identifier.bibliographicCitationMOLECULAR BRAIN RESEARCH , Vol.127(1-2) : 146-149, 2004-
dc.identifier.rimsid37383-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
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