Cited 34 times in
Serum high sensitivity C-reactive protein is associated with carotid intima-media thickness in type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 김형진 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-07-14T16:48:42Z | - |
dc.date.available | 2015-07-14T16:48:42Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111637 | - |
dc.description.abstract | BACKGROUND: High sensitivity C-reactive protein (hsCRP) is more sensitive than standard C-reactive protein (CRP) assay in evaluating the risk of coronary heart disease and other atherosclerotic events. By this time, there are several reports that type 2 diabetic subjects have higher serum levels of hsCRP than those of non-diabetic subjects. However, there are few reports about factors which have influence upon the level of serum hsCRP in type 2 diabetic subjects. We had evaluated the association of serum hsCRP level with risk factors of cardiovascular diseases and carotid intima-media thickness (IMT) in type 2 diabetic subjects. METHODS: One hundred and five patients (59 men and 46 women) with type 2 diabetes were recruited. Subjects with severe cardiovascular diseases were excluded. All subjects were undergone carotid ultrasonography for evaluation of carotid IMT. Serum hsCRP concentrations were measured. RESULTS: Serum hsCRP level was correlated with mean left IMT (r = 0.366, P = 0.003), maximal left IMT (r = 0.370, P = 0.002), mean right IMT (r = 0.281, P = 0.023) and maximal right IMT (r = 0.370, P = 0.002), body mass index (r = 0.377, P < 0.001), waist circumference (r = 0.342, P < 0.001), waist-hip ratio (r = 0.229, P = 0.020), serum total cholesterol (r = 0.202, P = 0.024), serum triglyceride (r = 0.292, P = 0.022) and serum low-density lipoprotein (r = 0.133, P = 0.044). CONCLUSION: Our result shows that serum hsCRP level is correlated with carotid IMT and the risk factors of cardiovascular diseases and may be useful to predict accelerated atherosclerotic process in type 2 diabetic subjects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | S115~S120 | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Body Size | - |
dc.subject.MESH | C-Reactive Protein/metabolism* | - |
dc.subject.MESH | Carotid Arteries/pathology* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/blood* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/pathology* | - |
dc.subject.MESH | Diabetic Angiopathies/blood | - |
dc.subject.MESH | Diabetic Angiopathies/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Tunica Intima/pathology* | - |
dc.subject.MESH | Tunica Media/pathology* | - |
dc.title | Serum high sensitivity C-reactive protein is associated with carotid intima-media thickness in type 2 diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Hae Jin Kim | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Hyung Jin Kim | - |
dc.contributor.googleauthor | Sung Kil Lim | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Sihoon Lee | - |
dc.contributor.googleauthor | Yoo Mee Kim | - |
dc.identifier.doi | 10.1016/j.diabres.2004.05.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 15563960 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168822704001457 | - |
dc.subject.keyword | High sensitivity C-reactive protein | - |
dc.subject.keyword | Carotid intima-media thickness | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Hyung Jin | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 66 | - |
dc.citation.number | Suppl 1 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 120 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.66(Suppl 1) : 115-120, 2004 | - |
dc.identifier.rimsid | 37380 | - |
dc.type.rims | ART | - |
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