Cited 20 times in
Nω-nitro-l-arginine methyl ester attenuates lithium-induced c-Fos, but not conditioned taste aversion, in rats
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.contributor.author | 장정원 | - |
dc.date.accessioned | 2015-07-14T16:48:33Z | - |
dc.date.available | 2015-07-14T16:48:33Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0168-0102 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111632 | - |
dc.description.abstract | Lithium chloride (LiCl) at doses sufficient to induce conditioned taste aversion (CTA) causes c-Fos expression in the relevant brain regions and activates the hypothalamic-pituitary-adrenal (HPA) axis. It has been suggested that nitric oxide (NO) in the central nervous system may play a role not only in the activation of HPA axis but also in CTA learning, and that LiCl may activate the brain NO system. To determine the role of NO in lithium-induced CTA, we examined the lithium-induced CTA, brain c-Fos expression, and plasma corticosterone level with Nomega-nitro-L-arginine methyl ester (L-NAME) pretreatment. Intraperitoneal L-NAME (30 mg/kg) given 30 min prior to LiCl significantly decreased lithium-induced c-Fos expression in the brain regions implicated in CTA learning, such as the hypothalamic paraventricular nucleus (PVN), central nucleus of amygdala (CeA), and nucleus tractus of solitarius. However, either the lithium-induced CTA acquisition or the increase in plasma corticosterone was not attenuated by l-NAME pretreatment. These results suggest that NO may be involved in lithium-induced neuronal activation of the brain regions, but not in the CTA acquisition or the HPA axis activation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 485~492 | - |
dc.relation.isPartOf | NEUROSCIENCE RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Nω-nitro-l-arginine methyl ester attenuates lithium-induced c-Fos, but not conditioned taste aversion, in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Jeong Won Jahng | - |
dc.contributor.googleauthor | Jong-Ho Lee | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.googleauthor | Thomas A. Houpt | - |
dc.contributor.googleauthor | Gun Tae Kim | - |
dc.contributor.googleauthor | Joo Young Lee | - |
dc.contributor.googleauthor | Seoul Lee | - |
dc.identifier.doi | 10.1016/j.neures.2004.08.016 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02365 | - |
dc.identifier.eissn | 1872-8111 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168010204002299 | - |
dc.subject.keyword | Conditioned taste aversion | - |
dc.subject.keyword | Lithium chloride | - |
dc.subject.keyword | Nitric oxide | - |
dc.subject.keyword | c-Fos | - |
dc.subject.keyword | Hypothalamic-pituitary-adrenal axis | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Jahng, Jeong Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 50 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 485 | - |
dc.citation.endPage | 492 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE RESEARCH, Vol.50(4) : 485-492, 2004 | - |
dc.identifier.rimsid | 37378 | - |
dc.type.rims | ART | - |
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