4 322

Cited 7 times in

Increased nephron volume is not a cause of supranormal renographic differential renal function in patients with ureteropelvic junction obstruction

Authors
 WON SIK HAM  ;  HYEON JOO JEONG  ;  DONG KEE KIM  ;  JANG HWAN KIM  ;  SANG WON HAN 
Citation
 JOURNAL OF UROLOGY, Vol.172(3) : 1108-1110, 2004 
Journal Title
 JOURNAL OF UROLOGY 
ISSN
 0022-5347 
Issue Date
2004
MeSH
Biopsy ; Child ; Child, Preschool ; Female ; Humans ; Hydronephrosis/congenital ; Hydronephrosis/pathology* ; Hydronephrosis/physiopathology* ; Hydronephrosis/surgery ; Infant ; Kidney/physiopathology* ; Kidney Glomerulus/pathology ; Kidney Pelvis/surgery ; Male ; Nephrons/pathology* ; Radioisotope Renography ; Ureteral Obstruction/congenital ; Ureteral Obstruction/pathology* ; Ureteral Obstruction/physiopathology* ; Ureteral Obstruction/surgery
Keywords
nephrons ; kidney function tests ; hydronephrosis
Abstract
PURPOSE: Increasing clinical importance is being placed on the role of differential renal function (DRF) in the management of congenital ureteropelvic junction obstruction. Supranormal DRF of the hydronephrotic kidney on renal scan is a puzzling phenomenon and is hypothesized to be due to an increase in single nephron filtration or nephron volume without sound evidence. We studied the histopathological changes of hydronephrotic kidneys to determine whether glomerular hypertrophy underlies supranormal DRF. MATERIALS AND METHODS: We retrospectively evaluated the records of 3 females and 32 males with unilateral congenital hydronephrosis who underwent pyeloplasty. Mean patient age at operation was 12.6 months (range 0.1 to 144). Needle biopsies from 3 different sites at the lower pole of the kidney were performed during surgery. To evaluate the presence of glomerular hypertrophy, the maximal planar area of glomeruli was measured under light microscopy using an image analyzer. Tissue samples obtained from kidneys without a history of urinary tract disease at autopsy were used as controls. The mean glomerular areas of the patient and control groups were evaluated according to DRF and age. RESULTS: The mean glomerular area values of the patient group were smaller than those of the control group, except for 4 patients. The glomerular areas of the hydronephrotic kidneys with supranormal DRF were not significantly different from those of the control group. Instead, the probability of larger renal glomeruli increased with decreasing DRF (p = 0.1155). CONCLUSIONS: Increased nephron volume can be discounted as a cause of supranormal DRF.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022534705615741
DOI
10.1097/01.ju.0000135324.17766.5f
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ki(김동기)
Kim, Jang Hwan(김장환) ORCID logo https://orcid.org/0000-0002-9056-7072
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111602
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse