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Polymorphism p53 codon-72 and invasive cervical cancer: a meta-analysis

Authors
 S.H. Jee  ;  S.Y. Won  ;  S.S. Ji  ;  J.S. Park  ;  J.E. Lee  ;  J.E. Yun 
Citation
 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Vol.85(3) : 301-308, 2004 
Journal Title
 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 
ISSN
 0020-7292 
Issue Date
2004
MeSH
Adenocarcinoma/genetics* ; Carcinoma, Squamous Cell/genetics* ; Case-Control Studies ; Codon ; Female ; Genetic Predisposition to Disease ; Humans ; Odds Ratio ; Polymorphism, Genetic ; Seroepidemiologic Studies ; Tumor Suppressor Protein p53/genetics* ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/genetics*
Keywords
Polymorphism ; Codon 72 of p53 ; Cervical cancer
Abstract
OBJECTIVES: Although some studies have reported that the arginine isoform on codon 72 of p53 increases the susceptibility to invasive cervical cancer, such data remain controversial. The objective of this study was to quantitatively summarize the evidence for such a relationship. METHODS: Our data sources consisted of a MEDLINE search of the literature published before December 2002, bibliography review, and expert consultation. Thirty-seven studies met the inclusion criteria. Information on sample size, study design, Hardy-Weinberg equilibrium, and method of genotype determination was abstracted by two reviewers using a standardized protocol. The overall odds ratio (OR) of the p53 gene on invasive cervical cancer was estimated using the Mantel-Haenzel method. RESULTS: The overall OR (95% confidence interval) for cervical cancer among those with the homozygous mutant (Arg/Arg) was 1.2 (1.1-1.3, P=0.001) compared with those with the heterozygous mutant (Arg/Pro). By a cellular type of cervical cancer, the overall OR among those with Arg/Arg was statistically significant in adenocarcinomas (1.7, 1.1-2.6, P=0.024), but not in squamous cell carcinomas (1.1, 0.9-1.2, P=0.960), compared with Pro/Pro. Compared with Arg/Pro, the OR among those with Arg/Arg was statistically significant in HPV types 16 (1,5, 1.2-2.0, P=0.002). CONCLUSIONS: Overall, the p53 gene was associated with increased risk for invasive cervical cancer. However, the risk varied by country, cellular, and HPV type.
Full Text
http://www.sciencedirect.com/science/article/pii/S0020729203004405
DOI
10.1016/j.ijgo.2003.08.017
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111587
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