Endogenous urinary steroids in premenopausal women with uterine leiomyomas

Abstract

Objectives: To study the effect of endogenous steroids on the presence of uterine leiomyomas. Methods: Urine samples of 27 premenopausal women with leiomyomas and 25 age-matched healthy premenopausal women were collected. The concentration of estrogens and androgens in the urine samples of the two groups were determined using a gas chromatography mass spectrometer and the two groups were compared. To study metabolic changes in patients indirectly, the concentration ratios of precursor metabolite to product metabolite of the two groups were also compared. Results: Urinary concentrations of 17β-estradiol, 5-androstene-3β, 16β, 17β, triol, 11-keto-ethiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, THS, THA, THE, α-cortol and β-cortol were significantly higher in patients than in controls. The concentration ratios of 17β-estradiol/estrone and 11/β-hydroxy-ethiocholanolone/11β-hydroxy-androsterone increased in patients. Conclusions: The presence of uterine leiomyomas correlates with an increase in urinary concentrations of estrogens and androgens, and it appears to be caused by a decrease in patients’ metabolism of steroids.