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Endogenous urinary steroids in premenopausal women with uterine leiomyomas

Authors
 B.H. Jung  ;  S.W. Bai  ;  B.C. Chung 
Citation
 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Vol.84(1) : 55-60, 2004 
Journal Title
 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 
ISSN
 0020-7292 
Issue Date
2004
MeSH
Adult ; Androgens/urine* ; Androstenols/urine ; Androsterone/analogs & derivatives* ; Androsterone/urine ; Case-Control Studies ; Corticosterone/analogs & derivatives* ; Corticosterone/urine ; Cortodoxone/analogs & derivatives* ; Cortodoxone/urine ; Dehydroepiandrosterone/urine ; Estradiol/urine ; Estrogens/urine* ; Estrone/urine ; Etiocholanolone/analogs & derivatives* ; Etiocholanolone/urine ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Leiomyoma/metabolism* ; Leiomyoma/urine ; Middle Aged ; Pregnanes/urine ; Premenopause ; Tetrahydrocortisone/urine ; Uterine Neoplasms/metabolism* ; Uterine Neoplasms/urine
Abstract
Objectives: To study the effect of endogenous steroids on the presence of uterine leiomyomas. Methods: Urine samples of 27 premenopausal women with leiomyomas and 25 age-matched healthy premenopausal women were collected. The concentration of estrogens and androgens in the urine samples of the two groups were determined using a gas chromatography mass spectrometer and the two groups were compared. To study metabolic changes in patients indirectly, the concentration ratios of precursor metabolite to product metabolite of the two groups were also compared. Results: Urinary concentrations of 17β-estradiol, 5-androstene-3β, 16β, 17β, triol, 11-keto-ethiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, THS, THA, THE, α-cortol and β-cortol were significantly higher in patients than in controls. The concentration ratios of 17β-estradiol/estrone and 11/β-hydroxy-ethiocholanolone/11β-hydroxy-androsterone increased in patients. Conclusions: The presence of uterine leiomyomas correlates with an increase in urinary concentrations of estrogens and androgens, and it appears to be caused by a decrease in patients’ metabolism of steroids.
Full Text
http://www.sciencedirect.com/science/article/pii/S0020729203003369
DOI
10.1016/S0020-7292(03)00336-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111586
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