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Prognosis of thymic epithelial tumors according to the new World Health Organization histologic classification

 Moo Suk Park  ;  Kyung Young Chung  ;  Se Kyu Kim  ;  Sung Kyu Kim  ;  Joo Hang Kim  ;  Joon Chang  ;  Young Sam Kim  ;  Jae Ho Chung  ;  Woo Ick Yang  ;  Kil Dong Kim 
 ANNALS OF THORACIC SURGERY, Vol.78(3) : 992-998, 2004 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Survival Rate ; Thymoma/diagnosis ; Thymoma/mortality ; Thymoma/pathology* ; Thymoma/secondary ; Thymoma/therapy* ; Thymus Neoplasms/diagnosis ; Thymus Neoplasms/mortality ; Thymus Neoplasms/pathology* ; Thymus Neoplasms/therapy* ; World Health Organization
BACKGROUND: The aim of this study was to document the prognosis of thymic epithelial tumors (TETs) according to new the World Health Organization (WHO) classification.
METHODS: We retrospectively reviewed 150 patients with TETs that were confirmed pathologically during 11 years (from 1992 to 2002) in Severance Hospital, Seoul, Korea.
RESULTS: TETs were classified as type A, AB, B1, B2, B3, or C, tumors and these represented 7 (4.7%), 26 (17.3%), 13 (8.7%), 45 (30.0%), 26 (17.3%), and 33 (22.0%) cases, and the 5-year survival rates were 100%, 93%, 89%, 82%, 71%, and 23%, respectively. Their Masaoka stages were I, II, III, IVa, and IVb, with 53 (35.3%), 39 (26.0%), 20 (13.3%), 22 (14.7%), and 16 (10.7%) cases. Tumor invasiveness, recurrence, completeness of resection, and tumor-related death were more frequent in types AB, B2, B3, and C than in types A and B1. Multivariate analysis showed that Masaoka stage (p < 0.001) and the WHO classification (p = 0.019) were significant independent prognostic factors.
CONCLUSIONS: The WHO classification is associated with tumor invasiveness, recurrence, completeness of resection, and tumor-related death, and has good correlation with Masaoka stage. The WHO histologic subtypes are an independently significant prognostic factor with respect to survival in our multivariate analysis. Types AB, B2, B3, and C showed invasive behaviors and R1 or R2 resections were frequently performed. Postoperative adjuvant radiotherapy was effective, but long-term follow-up is recommended because of decreased survival after 5 years following operation. The WHO classification may be helpful in clinical practice for the assessment and treatment of TET patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyu(김세규)
Kim, Joo Hang(김주항)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
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