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Interleukin-18 Is Associated with Increased Severity of Atopic Dermatitis in Children

Authors
 Sohn, Myung Hyun  ;  Lee, Kyung Eun  ;  Kim, Kyu-Earn 
Citation
 ALLERGY AND ASTHMA PROCEEDINGS, Vol.25(3) : 181-184, 2004 
Journal Title
 ALLERGY AND ASTHMA PROCEEDINGS 
ISSN
 1088-5412 
Issue Date
2004
MeSH
Antigens, Bacterial/pharmacology ; Case-Control Studies ; Cell Culture Techniques ; Child ; Child, Preschool ; Cytokines/blood ; Dermatitis, Atopic/blood* ; Dermatitis, Atopic/etiology ; Enterotoxins/pharmacology ; Fas Ligand Protein ; Female ; Humans ; Infant ; Interleukin-18/blood* ; Interleukin-18/metabolism* ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism* ; Male ; Membrane Glycoproteins/blood ; Severity of Illness Index
Abstract
Atopic dermatitis (AD) is a chronic relapsing skin disease characterized by reduced interferon (IFN) production with concurrent up-regulation of interleukin (IL)-4. Recently, it was reported that IL-18, formerly called IFN -inducing factor, induces the production of T helper (Th)2-related cytokines without help from IL-12. This study was performed to evaluate the contribution of IL-18 in the pathogenesis of AD. Significantly higher serum IL-18 concentrations were found in patients with severe AD than in healthy subjects. Under staphylococcal enterotoxin B stimulation, IL-18 secretion was increased in peripheral blood mononuclear cells from patients with AD. There were significant differences in the concentrations of IL-10, IL-12, and soluble Fas ligand between AD patients and normal controls. In conclusion, increased serum IL-18 concentrations may be involved in the pathogenesis of AD.
Full Text
http://www.ingentaconnect.com/content/ocean/aap/2004/00000025/00000003/art00008?token=0051178882b680f7b76504c486646252e497b2f7a317b4d3b6a332b25757d5c4f6d4e227ae1d930a1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111499
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