Cited 12 times in
Radiation-induced alteration of pain-related signals in an animal model with bone invasion from cancer
DC Field | Value | Language |
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dc.contributor.author | 김은정 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 이배환 | - |
dc.date.accessioned | 2015-07-14T16:41:32Z | - |
dc.date.available | 2015-07-14T16:41:32Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111397 | - |
dc.description.abstract | Although radiotherapy is highly effective in relieving bone pain from cancer invasion, the mechanism of pain relief remains unclear. To explore the mechanism of radiotherapy-induced analgesia, we have developed an animal model of bone pain resulting from cancer invasion. Using this animal model system, radiation-induced pain response and pain-related signals in the spinal cord were analyzed. The hind paw model of bone pain from cancer invasion was developed by injecting transplantable hepatocellular carcinoma, HCa-1, into the periosteal membrane of the foot dorsum in C3H/HeJ mice. Bony invasion from HCa-1 cells was confirmed by histopathological examinations. We also measured the development of pain-associated behaviors. In this model, changes in the objective level of pain response after irradiation of the tumor were analyzed. Expression of pain-related host signals in the spinal cord, such as calcitonin gene-related peptide (CGRP), substance P, and c-fos, was investigated with immunohistochemical staining. In the histopathological examinations, bone invasion from HCa-1 cells was seen from day 7 and was evident at day 14 after injection. Measurable pain-associated behaviors were developed from day 7. In this model, mice treated with radiotherapy showed decreased objective levels of pain with a higher threshold to graded mechanical stimulation than did control mice from day 3 after irradiation. After irradiation of tumors, significant decreases in the expression of CGRP were shown in the spinal cord, whereas neither substance P nor c-fos showed any alteration. We developed a novel hind paw model of bone pain from cancer invasion that was confirmed by histopathological examination and measurable pain-associated behaviors. Radiotherapy decreased the objective level of pain and the underlying mechanism involved in the alteration of pain-related host signal, CGRP, in the spinal cord. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 179~186 | - |
dc.relation.isPartOf | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Neoplasms/complications | - |
dc.subject.MESH | Bone Neoplasms/radiotherapy* | - |
dc.subject.MESH | Bone Neoplasms/secondary* | - |
dc.subject.MESH | Calcitonin Gene-Related Peptide/metabolism | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Pain/etiology | - |
dc.subject.MESH | Pain/physiopathology* | - |
dc.subject.MESH | Signal Transduction/radiation effects* | - |
dc.subject.MESH | Spinal Cord/physiopathology | - |
dc.title | Radiation-induced alteration of pain-related signals in an animal model with bone invasion from cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | JINSIL SEONG | - |
dc.contributor.googleauthor | HEE CHUL PARK | - |
dc.contributor.googleauthor | BAE WHAN LEE | - |
dc.contributor.googleauthor | UN JUNG KIM | - |
dc.contributor.googleauthor | JIYOUNG KIM | - |
dc.identifier.doi | 10.1196/annals.1329.023 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00181 | - |
dc.identifier.eissn | 1749-6632 | - |
dc.identifier.pmid | 15659796 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1196/annals.1329.023/abstract | - |
dc.subject.keyword | pain in the bone | - |
dc.subject.keyword | animal model | - |
dc.subject.keyword | bone metastasis | - |
dc.subject.keyword | radiation | - |
dc.contributor.alternativeName | Kim, Un Jeng | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 1030 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 186 | - |
dc.identifier.bibliographicCitation | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1030 : 179-186, 2004 | - |
dc.identifier.rimsid | 35790 | - |
dc.type.rims | ART | - |
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