Development and validation study of the breast cancer risk appraisal for Korean women

Abstract

The purpose of the present study was to develop and validate breast cancer risk factors, which can be used to identify women who are at a high risk of developing breast cancer. Fourteen risk factors for breast cancer were identified from extensive literature reviews and in consultation with a panel of experts. A case-control study was conducted, which aimed to validate these 14 risk factors. Cases were selected from four university hospitals in Korea and controls were selected from health screening centers in Korea. Interviews were used to obtain exposure history of each participant to the 14 risk factors. Group differences between the cases and controls were analyzed using a chi-squared test and a logistic regression method. Among the 14 risk factors, six were identified as significant: meat consumption more than once a week (odds ratio [OR] = 1.56, confidence interval [CI] = 1.32–1.85), breast disease experience (OR = 3.08, CI = 1.49–6.37), less than two children (OR = 1.61, CI = 1.09–2.35), family history of breast cancer (OR = 8.99, CI = 3.89–20.76), and no breast-feeding experience (OR = 3.08, CI = 1.41–3.85). Based on the OR, the risk scores were calculated by the absolute size of the OR having a total of 100 points.