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Hepatitis B virus infection after renal transplantation in the presence of antibody to hepatitis B surface antigen immunity

DC FieldValueLanguage
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.contributor.author전재윤-
dc.contributor.author김유선-
dc.contributor.author백용한-
dc.contributor.author정효영-
dc.contributor.author한광협-
dc.date.accessioned2015-07-14T16:40:38Z-
dc.date.available2015-07-14T16:40:38Z-
dc.date.issued2004-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111367-
dc.description.abstractBACKGROUND AND AIM: Hepatitis B virus (HBV) infection has been known to be hampered by immunity against hepatitis B surface antigen (HBsAg). However, HBV with mutations within the common antigenic epitope of HBsAg, the "a" determinant region, can escape from humoral immunity. Moreover, HBV infection by "a" determinant mutants in chronic HBV patients has been reported after renal transplantation. In the present study, the authors investigated HBV infection after renal transplantation despite passive immunization or resolved HBV infection. METHODS: A total of 1682 patients who underwent a renal transplant between 1979 and 1998 at the Severance Hospital, Yonsei University College of Medicine, Korea, were enrolled. The sequence of the HBV genome was analyzed from two patients with antibody to HBsAg (anti-HBs) immunity. RESULTS: Of 1682 patients who were HBsAg negative before transplantation, 21 patients were found to be HBsAg positive, with elevated aspartate aminotransferase and alanine aminotransferase levels after transplantation. Interestingly, six of 21 (28.6%) patients were anti-HBs positive before the transplantation. Sequence analysis of the cloned HBV from two of six patients with anti-HBs immunity showed no evidence of significant mutations within the "a" determinant region, suggesting a wild-type of HBV. Their donors were not exposed to HBV before transplantation (all HBV markers were negative). Seven deaths of 21 patients were ascribed to HBV-related complications. CONCLUSIONS: Regardless of anti-HBs immunity, HBV infection occurred in immunosuppressed patients in a high endemic area. The molecular mechanism and clinical impact of HBV infection after renal transplantation in patients with anti-HBs immunity should be further reappraised.-
dc.description.statementOfResponsibilityopen-
dc.format.extent847~853-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHBase Sequence-
dc.subject.MESHClinical Trials as Topic-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B/etiology*-
dc.subject.MESHHepatitis B/immunology-
dc.subject.MESHHepatitis B Antibodies/blood*-
dc.subject.MESHHepatitis B Surface Antigens/immunology*-
dc.subject.MESHHepatitis B virus/genetics-
dc.subject.MESHHepatitis B virus/immunology*-
dc.subject.MESHHumans-
dc.subject.MESHImmunity-
dc.subject.MESHKidney Transplantation/adverse effects*-
dc.subject.MESHLiver Function Tests-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHPolymerase Chain Reaction-
dc.titleHepatitis B virus infection after renal transplantation in the presence of antibody to hepatitis B surface antigen immunity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKYUN-HWAN KIM-
dc.contributor.googleauthorSANG HOON AHN-
dc.contributor.googleauthorKWANG-HYUB HAN-
dc.contributor.googleauthorYOUNG MYOUNG MOON-
dc.contributor.googleauthorCHAE YOON CHON-
dc.contributor.googleauthorYU SEUN KIM-
dc.contributor.googleauthorKWAN SIK Lee-
dc.contributor.googleauthorYONG HAN PAIK-
dc.contributor.googleauthorHYO YOUNG CHUNG-
dc.identifier.doi10.1111/j.1440-1746.2003.03303.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid15242485-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2003.03303.x/abstract-
dc.subject.keyword‘a’ determinant mutants-
dc.subject.keywordantibody to hepatitis B surface antigen immunity-
dc.subject.keywordhepatitis B virus infection-
dc.subject.keywordrenal transplantation-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNamePaik, Yong Han-
dc.contributor.alternativeNameChung, Hyo Young-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.rights.accessRightsnot free-
dc.citation.volume19-
dc.citation.number8-
dc.citation.startPage847-
dc.citation.endPage853-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.19(8) : 847-853, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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