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Haemodynamic effects of a milrinone infusion without a bolus in patients undergoing off-pump coronary artery bypass graft surgery

Authors
 Y. L. Kwak  ;  Y. J. Oh  ;  Y. W. Hong  ;  S. H. Kim  ;  K. J. Yoo  ;  H. K. Shinn 
Citation
 ANAESTHESIA, Vol.59(4) : 324-331, 2004 
Journal Title
 ANAESTHESIA 
ISSN
 0003-2409 
Issue Date
2004
MeSH
Aged ; Cardiopulmonary Bypass ; Cardiotonic Agents/pharmacology* ; Drug Administration Schedule ; Female ; Hemodynamics/drug effects* ; Humans ; Infusions, Intravenous ; Internal Mammary-Coronary Artery Anastomosis/methods* ; Intraoperative Care/methods ; Male ; Middle Aged ; Milrinone/pharmacology* ; Oxygen/blood ; Partial Pressure ; Phosphodiesterase Inhibitors/pharmacology*
Keywords
Milrinone ; Coronary artery bypass surgery ; off‐pump
Abstract
The haemodynamic effects of a continuous infusion of milrinone without an initial bolus dose were evaluated in patients undergoing off-pump coronary artery bypass graft surgery. After internal mammary artery harvest, milrinone 0.5 microg.min(-1).kg(-1) (29 patients) or a normal saline infusion (33 patients) was started and continued until all graft anastomoses were completed. Haemodynamic variables were recorded before application of the tissue stabiliser, at 1, 3, 5 and 10 min after the application of the stabiliser, and after its removal. The administration of a milrinone infusion was associated with a smaller decrease in cardiac output and mixed venous oxygen saturation during all the coronary artery anastomoses, with no severe complications and a decreased dose of norepinephrine infused to maintain systemic arterial pressure.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2004.03659.x/abstract
DOI
10.1111/j.1365-2044.2004.03659.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Yoo, Kyung Jong(유경종) ORCID logo https://orcid.org/0000-0002-9858-140X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111352
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