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Proteomic analysis distinguishes basaloid carcinoma as a distinct subtype of nonsmall cell lung carcinoma

 Long Shan Li  ;  Hyunki Kim  ;  Hoguen Kim  ;  Joon Chang  ;  Young-Ki Paik  ;  Kang-Sik Park  ;  Kyung Young Chung  ;  Dong Hwan Shin  ;  Se Hoon Kim  ;  Hwanseok Rhee 
 PROTEOMICS, Vol.4(11) : 3394-3400, 2004 
Journal Title
Issue Date
Carcinoma, Non-Small-Cell Lung/classification* ; Carcinoma, Non-Small-Cell Lung/metabolism* ; Carcinoma, Non-Small-Cell Lung/pathology ; Down-Regulation ; Humans ; Lung/pathology ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Proteome/metabolism* ; Proteomics* ; Reverse Transcriptase Polymerase Chain Reaction ; Up-Regulation
Hierarchical cluster analysis ; Histopathologic type ; Lung cancer
The histopathologic type of lung cancer is known to be correlated with tumor behavior and prognosis. However, this classification is subjective and no specific molecular markers have been identified. The aim of this study was to identify protein markers in different types of nonsmall cell lung cancers. Two-dimensional polyacrylamide gel electrophoresis analysis was performed with paired samples of three squamous cell carcinomas, three adenocarcinomas, four large cell carcinomas, and four basaloid carcinomas. We found that 25 proteins in 14 cases of lung cancer were differentially expressed compared to matched nontumorous lung tissues. Among these 25 proteins, 11 proteins were down-regulated and 14 were up-regulated in these four types of lung cancer. Alloalbumin venezia, selenium-binding protein 1, carbonic dehydratase, heat shock 20KD-like protein, and SM22 α protein were down-regulated in all 14 cases of lung cancer examined, whereas alpha enolase was consistently up-regulated. Supervised hierarchical cluster analysis based on the 25 differentially expressed proteins showed that basaloid carcinoma formed one independent group, whereas the other three cancer types were not uniquely classifiable. Our findings suggest that basaloid carcinoma is a unique subtype of nonsmall cell lung carcinoma.
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1. College of Medicine (의과대학) > Dept. of Clinical Genetics (임상유전학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Kim, Ho Keun(김호근)
Shin, Dong Hwan(신동환)
Li, Long Shan(이용산)
Rhee, Hwan Seok(이환석)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Chung, Kyung Young(정경영)
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