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Chemical, structural properties, and osteoconductive effectiveness of bone block derived from porcine cancellous bone

Authors
 Su-Hyang Kim  ;  Jung-Wook Shin  ;  Jin Woo Lee  ;  Woo Ick Yang  ;  James M. Mok  ;  Mun Soo Park  ;  Young Kon Kim  ;  Su-A Park 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol.68B(1) : 69-74, 2004 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 
ISSN
 1552-4973 
Issue Date
2004
MeSH
Animals ; Bone Transplantation ; Bone and Bones/chemistry* ; Bone and Bones/metabolism ; Calcium Phosphates/chemistry* ; Calcium Phosphates/metabolism ; Durapatite/chemistry* ; Durapatite/metabolism ; Microscopy, Electron, Scanning ; Swine ; X-Ray Diffraction
Keywords
porcine cancellous bone ; calcium phosphate ; heat treated ; osteoconductivity
Abstract
The purpose of this study is to determine the efficacy of bioactive calcium phosphate obtained from porcine cancellous bone for the treatment of bone defects and nonunion. Porcine cancellous bone blocks were heat treated at 1300 degrees C for 2 h. The chemical composition, calcium-to-phosphate ratio, and microstructure of the porcine bone blocks were examined. For in vivo implantation, bone defects were created on the anteromedial aspect of the proximal tibia in seven beagle dogs and the xenograft bone blocks were placed into these defects. Plain radiographs were taken at 2-week intervals for roentgenographic evaluation. At 12 weeks, the specimens were stained with hematoxylin and eosin (H&E). The composition and morphology of heat-treated porcine cancellous bone were found to be similar to heat-treated human cancellous bone. Radiographs showed union between the host bone/bone-block interfaces. At 12 weeks, uniform and substantial new bone formation was observed. It is concluded that heat-treated porcine cancellous bone demonstrated effective osteoconductivity. This high-temperature heat-treatment technique has several advantages, including decreased risk of disease transmission and immunoreactivity, while also offering excellent biocompatibility.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.10084/abstract
DOI
10.1002/jbm.b.10084
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111308
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