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Chronic Graft-versus-Host Disease of the Liver Presenting as an Acute Hepatitis following Nonmyeloablative Hematopoietic Stem Cell Transplantation

Authors
 Hoyoung Maeng  ;  Jae-Hyun Lee  ;  Yoo Hong Min  ;  Yun Woong Ko  ;  Jee Sook Hahn  ;  Seung Tae Lee  ;  June Won Cheong 
Citation
 International Journal of Hematology, Vol.79(5) : 501-504, 2004 
Journal Title
 International Journal of Hematology 
ISSN
 0925-5710 
Issue Date
2004
Abstract
Chronic graft-versus-host disease (GVHD) of the liver usually presents as an indolent cholestatic disease. We observed 3 patients in whom chronic GVHD of the liver after allogeneic nonmyeloablative hematopoietic stem cell transplantation (HSCT) presented with marked elevations of serum aminotransferases, clinically resembling acute viral hepatitis. The liver biopsies revealed predominant diffuse lobular injury and degenerative small bile ducts. Prompt administration of high-dose immunosuppressive therapy achieved a rapid improvement of liver enzymes and bilirubin levels. We conclude that a distinct syndrome of chronic hepatic GVHD presenting as an acute hepatitis should be considered as one possible explanation for hepatic dysfunction in patients who receive nonmyeloablative allogeneic HSCT.
Full Text
http://link.springer.com/article/10.1532/IJH97.A10319
DOI
10.1532/IJH97.A10319
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
고윤웅(Ko, Yun Woong)
맹호영(Maeng, Ho Young)
민유홍(Min, Yoo Hong) ORCID logo https://orcid.org/0000-0001-8542-9583
이승태(Lee, Seung Tae)
이재현(Lee, Jae Hyun) ORCID logo https://orcid.org/0000-0002-0760-0071
정준원(Cheong, June-Won) ORCID logo https://orcid.org/0000-0002-1744-0921
한지숙(Hahn, Jee Sook)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111286
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