Cited 79 times in
Analysis of gene expression profiles of hepatocellular carcinomas with regard to 18F-fluorodeoxyglucose uptake pattern on positron emission tomography
DC Field | Value | Language |
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dc.contributor.author | 이종두 | - |
dc.contributor.author | 최윤희 | - |
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김세종 | - |
dc.contributor.author | 김지수 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 유내춘 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 이재면 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | Lee, Jong Doo | - |
dc.contributor.author | Choi, Youn Hee | - |
dc.contributor.author | Kim, Kyung Sik | - |
dc.contributor.author | Kim, Se Jong | - |
dc.contributor.author | Park, Young Nyun | - |
dc.contributor.author | Park, Jeon Han | - |
dc.contributor.author | Yang, Woo Ick | - |
dc.contributor.author | Yoo, Nae Choon | - |
dc.contributor.author | Yun, Mi Jin | - |
dc.contributor.author | Lee, Jae Myun | - |
dc.contributor.author | Han, Kwang Hyup | - |
dc.contributor.author | Lee, Woo Jung | - |
dc.contributor.author | Kim, Ji Su | - |
dc.date.accessioned | 2015-07-14T16:36:54Z | - |
dc.date.available | 2015-07-14T16:36:54Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111243 | - |
dc.description.abstract | PURPOSE: 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan has been found to reflect tumour aggressiveness and prognosis in various types of cancer. In this study, the gene expression profiles of hepatocellular carcinomas (HCCs) were evaluated to determine whether HCCs with high 18F-FDG uptake have more aggressive biological potential than those with low uptake. METHODS: Surgical specimens were obtained from ten patients with HCC (six males and four females, age range 38-68 years). The tumour samples were divided into two groups based on the 18F-FDG PET scan findings: high 18F-FDG uptake (n=4) and low 18F-FDG uptake (n=6). RESULTS: The pathological tumour grade was closely correlated with the 18F-FDG uptake pattern: HCCs with high 18F-FDG uptake were pathologically Edmondson-Steiner grade III, while those with low uptake were either grade II or grade II with a focal area of grade III. The total RNA was extracted from the frozen tissues of all HCCs (n=10) and adjacent non-cancerous tissue (n=7). The gene expression profiles were evaluated using an oligoDNA microarray. The HCCs with high 18F-FDG uptake showed increased expression of 11 genes--including vascular cell adhesion molecule-1, vinexin beta and core 1 UDP-galactose:N-acetylgalactosamine-alpha-R-beta 1,3-galactosyltransferase and the natural killer cell inhibitory receptor--compared to those with low uptake (p<0.005). Nine genes, including regulator of mitotic spindle assembly 1, grb2-related adaptor protein and beta-1,3-n-acetylglucosaminyltransferase, were repressed. CONCLUSION: Gene expression is closely related to cell survival, cell-to-cell adhesion or cell spreading; therefore, HCCs with high 18F-FDG uptake appear to have more aggressive biological properties than those with low uptake. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnostic imaging* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics | - |
dc.subject.MESH | Carcinoma, Hepatocellular/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18/pharmacokinetics* | - |
dc.subject.MESH | Gene Expression Profiling/methods | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Liver Neoplasms/genetics | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Proteins/metabolism* | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis/methods | - |
dc.subject.MESH | Organ Specificity | - |
dc.subject.MESH | Radionuclide Imaging | - |
dc.subject.MESH | Radiopharmaceuticals/pharmacokinetics | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Statistics as Topic | - |
dc.subject.MESH | Tissue Distribution | - |
dc.title | Analysis of gene expression profiles of hepatocellular carcinomas with regard to 18F-fluorodeoxyglucose uptake pattern on positron emission tomography | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Sang Moo Lim | - |
dc.contributor.googleauthor | Naechun Yoo | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.contributor.googleauthor | Ji Su Kim | - |
dc.contributor.googleauthor | Youn-Hee Choi | - |
dc.contributor.googleauthor | Youjeong Choi | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.identifier.doi | 10.1007/s00259-004-1602-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A04145 | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02457 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03071 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A00969 | - |
dc.relation.journalcode | J00833 | - |
dc.identifier.eissn | 1619-7089 | - |
dc.identifier.pmid | 15278306 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00259-004-1602-1 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | F-FDG uptake | - |
dc.subject.keyword | Positron emission tomography | - |
dc.subject.keyword | Gene expression profile | - |
dc.subject.keyword | OligoDNA microarray | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.alternativeName | Choi, Youn Hee | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Kim, Ji Su | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Yoo, Nae Choon | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Choi, Youn Hee | - |
dc.contributor.affiliatedAuthor | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yoo, Nae Choon | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Lee, Jae Myun | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Ji Su | - |
dc.contributor.affiliatedAuthor | 최윤희 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1621 | - |
dc.citation.endPage | 1630 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.31(12) : 1621-1630, 2004 | - |
dc.identifier.rimsid | 36230 | - |
dc.type.rims | ART | - |
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