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Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in Sprague-Dawley rats

Authors
 Myung Sil Hwang  ;  Mi Sun Park  ;  Ji-Young Moon  ;  Ji Sun Lee  ;  Young Na Yum  ;  Eungkyung Yoon  ;  Hyomin Lee  ;  Ki Taek Nam  ;  Byung Mu Lee  ;  Seung Hee Kim  ;  Ki Hwa Yang 
Citation
 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol.69(24) : 2157-2165, 2006 
Journal Title
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
ISSN
 1528-7394 
Issue Date
2006
MeSH
Animals ; Aristolochiaceae/chemistry* ; Aristolochic Acids/toxicity* ; Feeding Behavior/drug effects ; Female ; Kidney/drug effects ; Kidney/pathology ; Male ; No-Observed-Adverse-Effect Level ; Plant Extracts/toxicity ; Rats ; Rats, Sprague-Dawley ; Stomach/drug effects ; Stomach/pathology ; Weight Gain
Abstract
The subchronic toxicity of Aristolochiae fructus containing aristolochic acids (AAs), a natural component in the Aristolochiaceae family, was investigated. The A. fructus was daily administered by gavage to male and female rats for 90 d at dose levels of 21.35, 213.5, and 2135 mg/kg (equivalent to 0.05, 0.5, and 5 mg/kg as AAs, respectively). During the test period, clinical signs, mortality, body weights, food and water consumption, hematology, serum biochemistry, organ weights, and histopathology were examined. Significant decreases in body weight gain were noted in the high-dose group receiving both the aqueous extract of A. fructus and AAs. Decreases in food consumption were noted beginning at 50 d and did not recover in the high-dose group of aqueous extract of A. fructus and AAs. Irrespective of dose, water consumption was not affected. There was no mortality or adverse clinical signs, hematology, or serum biochemistry in the treatment groups versus control. Nephrotoxicity and hyperplasia of epithelial cells in the forestomach were observed in rats receiving the highest dose of aqueous extract of A. fructus and at doses of ≥ 0.5 mg/kg/day AAs. For both genders, the no-observed-adverse-effect level (NOAEL) for A. fructus based on this subchronic study in rats was considered to be 21.3 mg/kg/d.
Full Text
http://www.tandfonline.com/doi/abs/10.1080/15287390600747965
DOI
10.1080/15287390600747965
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111124
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