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급성 Acetaminophen 중독시 복용량에 의한 N-Acetylcystelne의 사용은 적절한가?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이한식 | - |
dc.contributor.author | 정성필 | - |
dc.contributor.author | 김민정 | - |
dc.contributor.author | 박유석 | - |
dc.date.accessioned | 2015-06-10T13:09:30Z | - |
dc.date.available | 2015-06-10T13:09:30Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1738-1320 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111116 | - |
dc.description.abstract | Purpose: In many Korean hospitals, serum acetaminophen concentrations in cases of overdose cannot be measured initially because of inadequate laboratory facilities. Under these circumstances, physicians base the administration of the antidote, N-acetylcysteine, on ingestion amounts as determined by initial history taking. We therefore examined the correlated between ingested amounts and serum acetaminophen concentrations. Methods: Medical records were reviewed retrospectively for patients who presented to the ED with acetaminophen overdose between January 2002 and March 2006. Fifty-nine patients were recruited and sixteen patients were excluded. The forty-three remaining patients were placed into either the high-risk or low-risk group based on their ingested amount (140 mg/kg), and were separately categorized into the toxic or non-toxic group based on their serum acetaminophen concentrations, according to the Rurnack-Matthew nomogram. Results: Ten patients (83.3%) among twelve in the high-risk group were found to have non-toxic serum concentrations, and just one patient (3.2%) among thirty-one in the low-risk group fell into the toxic group based on their serum concentrations. The sensitivity and specificity of risk stratification of the ingested amount as a predictor of intoxication requiring antidote therapy were 66.7% and 75.0%, respectively. Conclusion: This study suggests that the therapeutic decision for acetaminophen overdose should not be based solely on ingested amount only, but requires assessment of acetaminophen concentration. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 107~112 | - |
dc.relation.isPartOf | Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 급성 Acetaminophen 중독시 복용량에 의한 N-Acetylcystelne의 사용은 적절한가? | - |
dc.title.alternative | Is N-acetylcysteine Treatment Based on Ingestion Amount Valid in Acute Acetaminophen Overdose Patients? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Emergency Medicine (응급의학) | - |
dc.contributor.googleauthor | 김태근 | - |
dc.contributor.googleauthor | 김민정 | - |
dc.contributor.googleauthor | 이진희 | - |
dc.contributor.googleauthor | 박유석 | - |
dc.contributor.googleauthor | 정성필 | - |
dc.contributor.googleauthor | 이한식 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03278 | - |
dc.contributor.localId | A03625 | - |
dc.contributor.localId | A00470 | - |
dc.contributor.localId | A01592 | - |
dc.relation.journalcode | J01862 | - |
dc.subject.keyword | Acetaminophen | - |
dc.subject.keyword | Overdose | - |
dc.subject.keyword | N-acetylcysteine | - |
dc.contributor.alternativeName | Lee, Hahn Shick | - |
dc.contributor.alternativeName | Chung, Sung Pil | - |
dc.contributor.alternativeName | Kim, Min Joung | - |
dc.contributor.alternativeName | Park, Yoo Seok | - |
dc.contributor.affiliatedAuthor | Lee, Hahn Shick | - |
dc.contributor.affiliatedAuthor | Chung, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Min Joung | - |
dc.contributor.affiliatedAuthor | Park, Yoo Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 4 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 107 | - |
dc.citation.endPage | 112 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.4(2) : 107-112, 2006 | - |
dc.identifier.rimsid | 39380 | - |
dc.type.rims | ART | - |
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