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급성 Acetaminophen 중독시 복용량에 의한 N-Acetylcystelne의 사용은 적절한가?

DC Field Value Language
dc.contributor.author이한식-
dc.contributor.author정성필-
dc.contributor.author김민정-
dc.contributor.author박유석-
dc.date.accessioned2015-06-10T13:09:30Z-
dc.date.available2015-06-10T13:09:30Z-
dc.date.issued2006-
dc.identifier.issn1738-1320-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111116-
dc.description.abstractPurpose: In many Korean hospitals, serum acetaminophen concentrations in cases of overdose cannot be measured initially because of inadequate laboratory facilities. Under these circumstances, physicians base the administration of the antidote, N-acetylcysteine, on ingestion amounts as determined by initial history taking. We therefore examined the correlated between ingested amounts and serum acetaminophen concentrations. Methods: Medical records were reviewed retrospectively for patients who presented to the ED with acetaminophen overdose between January 2002 and March 2006. Fifty-nine patients were recruited and sixteen patients were excluded. The forty-three remaining patients were placed into either the high-risk or low-risk group based on their ingested amount (140 mg/kg), and were separately categorized into the toxic or non-toxic group based on their serum acetaminophen concentrations, according to the Rurnack-Matthew nomogram. Results: Ten patients (83.3%) among twelve in the high-risk group were found to have non-toxic serum concentrations, and just one patient (3.2%) among thirty-one in the low-risk group fell into the toxic group based on their serum concentrations. The sensitivity and specificity of risk stratification of the ingested amount as a predictor of intoxication requiring antidote therapy were 66.7% and 75.0%, respectively. Conclusion: This study suggests that the therapeutic decision for acetaminophen overdose should not be based solely on ingested amount only, but requires assessment of acetaminophen concentration.-
dc.description.statementOfResponsibilityopen-
dc.format.extent107~112-
dc.relation.isPartOfJournal of the Korean Society of Clinical Toxicology (대한임상독성학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title급성 Acetaminophen 중독시 복용량에 의한 N-Acetylcystelne의 사용은 적절한가?-
dc.title.alternativeIs N-acetylcysteine Treatment Based on Ingestion Amount Valid in Acute Acetaminophen Overdose Patients?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Emergency Medicine (응급의학)-
dc.contributor.googleauthor김태근-
dc.contributor.googleauthor김민정-
dc.contributor.googleauthor이진희-
dc.contributor.googleauthor박유석-
dc.contributor.googleauthor정성필-
dc.contributor.googleauthor이한식-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03278-
dc.contributor.localIdA03625-
dc.contributor.localIdA00470-
dc.contributor.localIdA01592-
dc.relation.journalcodeJ01862-
dc.subject.keywordAcetaminophen-
dc.subject.keywordOverdose-
dc.subject.keywordN-acetylcysteine-
dc.contributor.alternativeNameLee, Hahn Shick-
dc.contributor.alternativeNameChung, Sung Pil-
dc.contributor.alternativeNameKim, Min Joung-
dc.contributor.alternativeNamePark, Yoo Seok-
dc.contributor.affiliatedAuthorLee, Hahn Shick-
dc.contributor.affiliatedAuthorChung, Sung Pil-
dc.contributor.affiliatedAuthorKim, Min Joung-
dc.contributor.affiliatedAuthorPark, Yoo Seok-
dc.rights.accessRightsfree-
dc.citation.volume4-
dc.citation.number2-
dc.citation.startPage107-
dc.citation.endPage112-
dc.identifier.bibliographicCitationJournal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.4(2) : 107-112, 2006-
dc.identifier.rimsid39380-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers

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