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염증성 장질환 환자에서 수술 후 감염

Other Titles
 Risk of Postoperative Infection in Patients with Inflammatory Bowel Disease 
Authors
 안효석  ;  이상길  ;  김효종  ;  장재영  ;  주광로  ;  동석호  ;  김병호  ;  이정일  ;  장영운  ;  장린 
Citation
 Korean Journal of Gastroenterology, Vol.48(5) : 306-312, 2006 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
ISSN
 1598-9992 
Issue Date
2006
MeSH
Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/surgery* ; Crohn Disease/drug therapy ; Crohn Disease/surgery* ; Humans ; Immunologic Factors/adverse effects* ; Immunologic Factors/therapeutic use ; Immunosuppressive Agents/adverse effects* ; Immunosuppressive Agents/therapeutic use ; Infection/epidemiology ; Infection/etiology* ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology* ; Retrospective Studies
Keywords
Inflammatory bowel diseases ; Postoperative infection
Abstract
Background/Aims: The clinical course of patients with inflammatory bowel disease (IBD) frequently leads to the use of immunosuppressants and immunomodulators. We investigated the risk of postoperative infection in patients with IBD undergoing elective bowel surgery and whether the use of corticosteroid (CS) and/or 6-mercaptopurine/azathioprine (6-MP/AZA) before surgery was associated with the increased risk of postoperative infection.
Methods: Patients who were diagnosed as Crohn`s disease (n=25) or ulcerative colitis (n=19) and underwent elective bowel surgery between 1986 and 2005 were identified. Medical records were retrospectively analyzed including age, sex, duration of disease, indication for surgery, duration of surgery, type of surgery, type of postoperative infection, admission period, usage of CS and 6-MP/AZA, and preoperative laboratory values. There were 27 patients receiving CS alone, 6 patients receiving 6-MP/AZA alone or with CS, and 16 patients receiving neither CS nor 6-MP/AZA.
Results: There were 17 postoperative infections (38.6%) among IBD patients who had undergone surgery and wound infection was the most common type of infection (76.5%). In IBD patients, patients receiving CS had higher postoperative infection rate than those patients receiving neither CS nor 6-MP/AZA (p=0.039). Patients receiving CS in conjunction with 6-MP/AZA did not have significantly higher postoperative infection rate than those with CS only (p=0.415).
Conclusions: Preoperative use of CS in patients with IBD is associated with the increased risk of postoperative infections. Addition of 6-MP/AZA in patients receiving CS does not increase the risk of postoperative infections
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111090
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