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만성폐쇄성폐질환의 급성악화로 입원했던 환자에서 장기간 사망의 예측인자

Other Titles
 Predictors of Long-term Mortality after Hospitalization for Acute Exacerbation of COPD 
Authors
 정해선  ;  이진화  ;  천은미  ;  문진욱  ;  장중현 
Citation
 TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.60(2) : 205-214, 2006 
Journal Title
TUBERCULOSIS AND RESPIRATORY DISEASES
ISSN
 1738-3536 
Issue Date
2006
Keywords
COPD ; Mortality determinants ; Heart rate ; Right ventricular systolic pressure
Abstract
Background : Acute exacerbations form a major component of the socioeconomic burden of COPD. As yet, little information is available about the long-term outcome of patients who have been hospitalized with acute exacerbations, although high mortality rates have been reported. The aim of this study was to determine predictors of long-term mortality after hospitalization for acute exacerbation of COPD.

Materials and Methods : We performed a retrospective cohort study of consecutive patients admitted to the hospital for COPD exacerbation between 2000 through 2004. Patients who had died in hospital or within 6-months after discharge, had tuberculosis scar, pleural thickening or bronchiectasis by chest radiography or had been diagnosed with malignancy during follow-up periods were excluded.

Results : Mean age of patients was 69.5 years, mean follow-up duration was 49 months, and mean FEV1 was 1.00L (46% of predicted). Mortality was 35% (17/48). In the multivariate Cox regression analysis, heart rate of 100/min or more (p=0.003; relative risk [RR], 11.99; 95% confidence interval [CI], 2.34-61.44) and right ventricular systolic pressure (RVSP) of 35mmHg or more (p=0.019; RR, 6.85; 95% CI, 1.38-34.02) were independent predictors of mortality.

Conclusion : Heart rate and RVSP in stable state may be useful in predicting long-term mortality for COPD patients admitted to hospital with acute exacerbation.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Jin Wook(문진욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111065
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