Cited 148 times in
An essential complementary role of NF-kappa B pathway to microbicidal oxidants in Drosophila gut immunity
DC Field | Value | Language |
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dc.contributor.author | 유지환 | - |
dc.date.accessioned | 2015-06-10T13:07:36Z | - |
dc.date.available | 2015-06-10T13:07:36Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111056 | - |
dc.description.abstract | In the Drosophila gut, reactive oxygen species (ROS)-dependent immunity is critical to host survival. This is in contrast to the NF-κB pathway whose physiological function in the microbe-laden epithelia has yet to be convincingly demonstrated despite playing a critical role during systemic infections. We used a novel in vivo approach to reveal the physiological role of gut NF-κB/antimicrobial peptide (AMP) system, which has been ‘masked' in the presence of the dominant intestinal ROS-dependent immunity. When fed with ROS-resistant microbes, NF-κB pathway mutant flies, but not wild-type flies, become highly susceptible to gut infection. This high lethality can be significantly reduced by either re-introducing Relish expression to Relish mutants or by constitutively expressing a single AMP to the NF-κB pathway mutants in the intestine. These results imply that the local ‘NF-κB/AMP' system acts as an essential ‘fail-safe' system, complementary to the ROS-dependent gut immunity, during gut infection with ROS-resistant pathogens. This system provides the Drosophila gut immunity the versatility necessary to manage sporadic invasion of virulent pathogens that somehow counteract or evade the ROS-dependent immunity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3693~3701 | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antimicrobial Cationic Peptides/metabolism | - |
dc.subject.MESH | Antimicrobial Cationic Peptides/pharmacology | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drosophila/immunology* | - |
dc.subject.MESH | Drosophila/metabolism | - |
dc.subject.MESH | Drosophila/microbiology* | - |
dc.subject.MESH | Drosophila Proteins/metabolism | - |
dc.subject.MESH | Gastrointestinal Tract/microbiology* | - |
dc.subject.MESH | Immunity, Innate/drug effects | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.subject.MESH | Signal Transduction*/drug effects | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Transcription Factors/metabolism | - |
dc.title | An essential complementary role of NF-kappa B pathway to microbicidal oxidants in Drosophila gut immunity | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | 생체방어연구센터 | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Eun-Mi Ha | - |
dc.contributor.googleauthor | Chun-Taek Oh | - |
dc.contributor.googleauthor | Jae-Hong Seol | - |
dc.contributor.googleauthor | Paul T Brey | - |
dc.contributor.googleauthor | Ingnyol Jin | - |
dc.contributor.googleauthor | Dong Gun Lee | - |
dc.contributor.googleauthor | Jaesang Kim | - |
dc.contributor.googleauthor | Daekee Lee | - |
dc.contributor.googleauthor | Won-Jae Lee | - |
dc.identifier.doi | 10.1038/sj.emboj.7601233 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02522 | - |
dc.relation.journalcode | J00763 | - |
dc.identifier.eissn | 1460-2075 | - |
dc.identifier.pmid | 16858400 | - |
dc.contributor.alternativeName | Ryu, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Ryu, Ji Hwan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 3693 | - |
dc.citation.endPage | 3701 | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, Vol.25(15) : 3693-3701, 2006 | - |
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