Frontal dysfunction underlies depressive syndrome in Alzheimer disease: A FDG-PET study
Authors
Dong Young Lee ; Il Han Choo ; Jin Hyeong Jhoo ; Ki Woong Kim ; Jong Choul Youn ; Dong Su Lee ; Eun Joo Kang ; Jae Sung Lee ; Won Jun Kang ; Jong In Woo
Citation
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, Vol.14(7) : 625-628, 2006
OBJECTIVE: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD).
METHOD: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method.
RESULTS: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group.
CONCLUSIONS: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.