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Heterozygosities of 735 microsatellite markers and background linkage disequilibrium in the Korean population

Authors
 Kyung-A Lee  ;  Jong-Won Kim 
Citation
 EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.38(6) : 662-667, 2006 
Journal Title
EXPERIMENTAL AND MOLECULAR MEDICINE
ISSN
 1226-3613 
Issue Date
2006
MeSH
Adult ; Chromosomes, Human/genetics ; Female ; Heterozygote* ; Humans ; Korea ; Linkage Disequilibrium/genetics* ; Male ; Microsatellite Repeats/genetics*
Keywords
Asian continental ancestry group ; genetic markers ; linkage disequilibrium ; microsatellite repeats ; population characteristics
Abstract
Suitability of a specific population for linkage disequilibrium mapping studies of complex traits may be assessed by investigating the background linkage disequilibrium (BLD). We are unaware of studies for quantifying the degree of BLD in the Korean population, although the population may be a good candidate for mapping of complex trait genes through whole-genome association studies. It is useful to investigate the properties of genetic isolates in East Asia and to compare them to genetic isolates in Europe. We analyzed the extent of BLD in the Korean population using 735 microsatellite markers and compared the results with the Icelander population, which is one of the European expanded genetic isolates. The Korean population exhibited a level of BLD comparable with the Icelander population. The inference of population structure using the model with admixture showed that each individual has allele copies originating from K populations in equal proportions. Therefore, we believe that factors other than genetic distance, such as recent admixture, have not contributed to the level of BLD. Our results showed that the Korean population, which is an expanded population with no evidence of admixture, has a BLD level comparable with the Icelander population. Therefore, the Korean population can be used for fine mapping of either complex traits or monogenic diseases.
Files in This Item:
T200604490.pdf Download
DOI
10.1038/emm.2006.78
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110993
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