228 224

Cited 43 times in

Determinants of brain natriuretic peptide levels in patients with lone atrial fibrillation

Authors
 Sang Hak Lee  ;  Jae-Hun Jung  ;  Seung-Hyuk Choi  ;  Namho Lee  ;  Woo-Jung Park  ;  Dong-Jin Oh  ;  Chong-Yun Rhim  ;  Kwang-Hwak Lee 
Citation
 CIRCULATION JOURNAL, Vol.70(1) : 100-104, 2006 
Journal Title
 CIRCULATION JOURNAL 
ISSN
 1346-9843 
Issue Date
2006
MeSH
Aged ; Atrial Fibrillation/blood* ; Atrial Fibrillation/diagnostic imaging ; Atrial Function, Left ; Biomarkers/blood ; Echocardiography ; Female ; Heart Rate ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood* ; Reference Values ; Risk Factors
Keywords
Atria ; Atrial fibrillation ; Brain natriuretic peptide ; Hemodynamic process
Abstract
Background Although brain natriuretic peptide (BNP) is increasingly being used for screening and monitoring of congestive heart failure, its utility in patients with lone atrial fibrillation (AF) is unclear. Methods and Results Plasma BNP levels were measured and comprehensive transthoracic echocardiography was performed in 96 subjects (47: sinus rhythm, 49: AF). Patients with structural heart disease were excluded. Potential determinants of BNP levels were identified by univariate and multivariate analyses. Individuals with AF had higher BNP levels than those with sinus rhythm (150±114 vs 49±61 pg/ml, p<0.001) The left atrial (LA) volume index (r=0.63, p<0.001), the pulmonary artery systolic pressure (r=0.45, p=0.006), and the early mitral inflow velocity (E)/mitral annular velocity (E') (r=0.36, p=0.04) were found to be independently correlated with BNP level. The correlations between BNP level and LA volume index (p=0.001) or E/E' (p=0.03) were unaltered when subjects with sinus rhythm were removed from the analysis. Conclusions BNP levels significantly correlated with LA volume index and E/E' in patients with lone AF, which indicates that the BNP level may reflect early left ventricular dysfunction and LA enlargement in this patient population.
Files in This Item:
T200604417.pdf Download
DOI
10.1253/circj.70.100
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110981
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links