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아스피린 과민성을 동반하지 않은 Propyphenazone 유발성 천식 1예

Other Titles
 A Case of Propyphenazone Induced Asthma without Aspirin Sensitivity 
 이영주  ;  이용원  ;  박중원  ;  홍천수 
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.26(4) : 318-321, 2006 
Journal Title
Journal of Asthma, Allergy and Clinical Immunology(천식 및 알레르기)
Issue Date
Drug hypersensitivity ; Propyphenazone ; NSAIDs
Propyphenazone (1,2-dihydro-l,5-dimethyl-4-(isopropyl)-2-phenyl-pyrazol-3-one: isopropylantipyrine) is a nonsteroidal anti-inflammatory drug (NSAID) and widely used as a mild analgesic. Allergy-like reactions, such as urticaria, anaphylaxis, hemolytic anemia and serum sickness, have been regarded as pseudoallergic or intolerant reactions to this drug. Herein we report a case with propyphenazone-induced bronchoconstriction without cross-reaction with aspirin or acetaminophen. A 33-year-old female patient presented with cough and dyspnea which aggravated after taking NSAID compounds containing propyphenazone. To find the component inducing bronchial hyperresponsiveness, oral provocation tests were performed with aspirin, acetaminophen, NSAID compounds containing propyphenazone, and pure propyphenazone, respectively. After an oral challenge with NSAID compound containing propyphenazone or pure propyphenazone (150 mg), she showed significant changes in FEV1. However, an oral provocation test with aspirin (500 mg) or acetaminophen (900 mg) demonstrated negative results. This case was confirmed as asthma induced by propyphenazone without aspirin and acetaminophen sensitivity.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Lee, Young Joo(이영주)
Lee, Yong Won(이용원)
Hong, Chein Soo(홍천수)
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