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The interaction of hepatitis B virus X protein and protein phosphatase type 2 C alpha and its effect on IL-6
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 이재면 | - |
dc.date.accessioned | 2015-06-10T13:04:35Z | - |
dc.date.available | 2015-06-10T13:04:35Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110962 | - |
dc.description.abstract | HBx has been suggested as an important determinant mediating the pathological effects of HBV via interacting with various cellular proteins. To identify new HBx-interacting proteins and elucidate a possible mechanism associated with HBx and HBx-interacting proteins in hepatocellular carcinoma, yeast two-hybrid screening was performed. We identified a novel HBx-interacting protein, serine/threonine protein phosphatase PP2Cα, and investigated the effects of PP2Cα on HBx-mediated IL-6 regulation. The interaction between endogenous PP2Cα, and HBx was confirmed by co-immunoprecipitation. Recombinant HBx dose-dependently reduced enzyme activity of recombinant PP2Cα in vitro. While ectopically expressed PP2Cα in Cos-7 and Huh-7 cells reduced the expression of IL-6, overexpressed HBx with recombinant HBx-expressing adenovirus overcame PP2Cα-mediated IL-6 downregulation. In the response of IL-6, HBx phosphorylated STAT3 and recovered PP2Cα-mediated dephosphorylation of STAT3. These results supported that HBx might play a crucial role in HBV-associated hepatocarcinogenesis even in cases where cells express a negative regulator, PP2Cα. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 253~258 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The interaction of hepatitis B virus X protein and protein phosphatase type 2 C alpha and its effect on IL-6 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Ji Su Kim | - |
dc.contributor.googleauthor | Bo young Rho | - |
dc.contributor.googleauthor | Tae Ho Lee | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.10.028 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A03071 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X06022662 | - |
dc.subject.keyword | PP2Cα | - |
dc.subject.keyword | HBx | - |
dc.subject.keyword | IL-6 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.affiliatedAuthor | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | Lee, Jae Myun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 351 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 253 | - |
dc.citation.endPage | 258 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.351(1) : 253-258, 2006 | - |
dc.identifier.rimsid | 55931 | - |
dc.type.rims | ART | - |
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