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PPARγ activation induces CD36 expression and stimulates foam cell like changes in rVSMCs

DC FieldValueLanguage
dc.contributor.author이은직-
dc.contributor.author장양수-
dc.date.accessioned2015-06-10T13:02:55Z-
dc.date.available2015-06-10T13:02:55Z-
dc.date.issued2006-
dc.identifier.issn1098-8823-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110912-
dc.description.abstractThe purpose of the present study was to determine the role of peroxisome proliferator-activated receptor gamma (PPARγ) activation in smooth muscle cell (SMC) derived form cell formation. Wild and mutant type PPARγ were delivered by adenovirus then activated with troglitazone. The result of Oil Red O staining and FACS analysis showed that PPARγ activation induced lipid accumulation in rVSMCs. Furthermore, PPARγ activation reduced SMC marker genes such as α-actin while induced adipocyte differentiation marker genes and lipid metabolism-related genes as evidenced by RT-PCR and fluorescent immunocytochemistry. All these data demonstrate that PPARγ activation can drive foam cell like change in rVSMCs. Our results strongly suggest that PPARγ expression induces CD36 expression and adipocyte differentiation gene activation in the process of atherosclerosis and might be one of the crucial events in SMC derived foam cell formation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent165~174-
dc.relation.isPartOfPROSTAGLANDINS & OTHER LIPID MEDIATORS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHATP Binding Cassette Transporter 1-
dc.subject.MESHATP-Binding Cassette Transporters/genetics-
dc.subject.MESHActins/genetics-
dc.subject.MESHAdiponectin/genetics-
dc.subject.MESHAnimals-
dc.subject.MESHCD36 Antigens/genetics-
dc.subject.MESHCD36 Antigens/metabolism*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChromans/pharmacology-
dc.subject.MESHComplement Factor D/genetics-
dc.subject.MESHFatty Acid-Binding Proteins/genetics-
dc.subject.MESHFoam Cells/cytology-
dc.subject.MESHFoam Cells/metabolism*-
dc.subject.MESHGene Expression/drug effects-
dc.subject.MESHHypoglycemic Agents/pharmacology-
dc.subject.MESHLipid Metabolism/drug effects-
dc.subject.MESHMice-
dc.subject.MESHMuscle, Smooth, Vascular/cytology-
dc.subject.MESHMuscle, Smooth, Vascular/drug effects-
dc.subject.MESHMuscle, Smooth, Vascular/metabolism-
dc.subject.MESHMyocytes, Smooth Muscle/cytology-
dc.subject.MESHMyocytes, Smooth Muscle/drug effects-
dc.subject.MESHMyocytes, Smooth Muscle/metabolism*-
dc.subject.MESHPPAR alpha/genetics-
dc.subject.MESHPPAR gamma/agonists-
dc.subject.MESHPPAR gamma/genetics-
dc.subject.MESHPPAR gamma/metabolism*-
dc.subject.MESHPlatelet-Derived Growth Factor/pharmacology-
dc.subject.MESHProstaglandin D2/analogs & derivatives-
dc.subject.MESHProstaglandin D2/pharmacology-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHThiazolidinediones/pharmacology-
dc.subject.MESHTransfection-
dc.subject.MESHTroglitazone-
dc.subject.MESHTropomyosin/genetics-
dc.titlePPARγ activation induces CD36 expression and stimulates foam cell like changes in rVSMCs-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyun-Joung Lim-
dc.contributor.googleauthorSeahyoung Lee-
dc.contributor.googleauthorKuy-Sook Lee-
dc.contributor.googleauthorJin-Hee Park-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorEun Jig Lee-
dc.contributor.googleauthorHyun-Young Park-
dc.identifier.doi10.1016/j.prostaglandins.2006.06.006-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03050-
dc.contributor.localIdA03448-
dc.relation.journalcodeJ02555-
dc.identifier.pmid16939881-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1098882306000803-
dc.subject.keywordPPARγ-
dc.subject.keywordCD36-
dc.subject.keywordFoam cell-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordVSMC-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.rights.accessRightsnot free-
dc.citation.volume80-
dc.citation.number3-4-
dc.citation.startPage165-
dc.citation.endPage174-
dc.identifier.bibliographicCitationPROSTAGLANDINS & OTHER LIPID MEDIATORS, Vol.80(3-4) : 165-174, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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