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늑막삼출과 주변 림프절 침범이 동반된 다발성골수종 1예

Other Titles
 A Patient with IgA Monoclonal Gammopathy Presenting as Myelomatous Pleural Effusion with Axillary Node Involvement 
 Seo Jin Park  ;  Hyun Ju Sung  ;  Jeong Ho Kim  ;  Jae Woo Song  ;  Kyung Soon Song 
 Korean Journal of Hematology, Vol.41(1) : 41-45, 2006 
Journal Title
 Korean Journal of Hematology 
Issue Date
Multiple myeloma ; Pleural effusion ; IgA-lambda paraprotein
Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin, and the neoplastic plasma cells typically accumulate in the bone marrow with occasional involvement of other organs. Pleural effusion that is associated with multiple myeloma has been infrequently reported (<6%) and myelomatous pleural effusion is extremely rare (<1%). A 73-year-old woman was admitted to the department of dermatology for skin lesions on both arms and both ankles. A chest radiograph taken on admission showed a nodular lesion in the right upper lung and pleural effusion. Analysis of the pleural fluid revealed many atypical plasma cells, elevated levels of IgA (27.95g/L) and lambda light chain (9.16g/L), and monoclonal IgA-lambda paraprotein on immunofixation. The serum concentrations of IgA were elevated (33.08g/L) while the concentrations of IgG and IgM were decreased. Bone marrow aspirate smears contained increased levels of immature-appearing atypical plasma cells. This is only the third case of myelomatous pleural effusion that has been reported in Korea.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Song, Kyung Soon(송경순)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
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